N-1 and C-5 substituted cytosine, uracil and C-6 substituted pyrrolo[2, 3-d]pyrimidine derivatives: synthesis and biological evaluation (CROSBI ID 623739)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Stipković Babić, Maja ; Ratković, Ana ; Mihovilović, Moris ; Miošić, Mande ; Kurajica, Livia ; Blažeković, Filip ; Jukić, Marijana ; Glavaš-Obrovac, Ljubica ; Raić-Malić, Silvana ; Gazivoda Kraljević, Tatjana
engleski
N-1 and C-5 substituted cytosine, uracil and C-6 substituted pyrrolo[2, 3-d]pyrimidine derivatives: synthesis and biological evaluation
N-alkylated pyrimidine and pyrrolo[2, 3-d]pyrimidine derivatives have a great role in modern medicine and have shown rather marked antitumor and antiviral activities. The novel N-1 substituted and C-5 alkynylated N4-benzoylcytosine and uracil derivatives have been synthesized by N-alkylation of pyrimidine bases and subsequent Pd-catalysed Sonogashira cross-coupling reaction. N-1 triazolyl derivatives were afforded via 'click' reaction, while pyrrolo[2, 3-d]pyrimidine derivatives were prepared by in situ N-heteroannulation of C-5 alkynylated derivatives. The novel compounds were evaluated against HeLa, CaCo-2, Raji and K562 tumor cell lines.
Cytosine; uracil; pyrrolo[2; 3-d]pyrimidine; cytostatic evaluation
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Podaci o prilogu
130-130.
2015.
objavljeno
Podaci o matičnoj publikaciji
Knjiga sažetaka/ XXIV. Hrvatski skup kemičara i kemijskih inženjera
Ukić, Šime ; Bolanča, Tomislav
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
978-953-6894-54-3
Podaci o skupu
XXIV. hrvatski skup kemičara i kemijskih inženjera
poster
21.04.2015-24.04.2015
Zagreb, Hrvatska