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Pregled bibliografske jedinice broj: 759579

Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors


Balog, Marta; Miljanović, Milan; Blažetić, Senka; Labak, Irena; Ivić, Vedrana; Viljetić, Barbara; Borbely, Attila; Papp, Zoltán; Blažeković, Robert; Vari, Sandor G et al.
Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors // Croatian medical journal, 56 (2015), 2; 104-113 doi:10.3325/cmj.2015.56.104 (međunarodna recenzija, članak, znanstveni)


Naslov
Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors

Autori
Balog, Marta ; Miljanović, Milan ; Blažetić, Senka ; Labak, Irena ; Ivić, Vedrana ; Viljetić, Barbara ; Borbely, Attila ; Papp, Zoltán ; Blažeković, Robert ; Vari, Sandor G ; Fagyas, Miklós ; Heffer, Marija

Izvornik
Croatian medical journal (0353-9504) 56 (2015), 2; 104-113

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adrenal gland; sexual hormone receptors; leptin receptors

Sažetak
Aim was to compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress. Forty six 16-week-old Sprague- Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ERβ), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed. Body weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ERβ receptors in comparison to control group (P=0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P=0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P=0.033). Chronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to an increase in testosterone receptor in females and decrease in estrogen receptor in males.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Klinička bolnica "Dubrava",
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za biologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • MEDLINE
  • PubMedCentral (PMC)
  • ISI Alerting


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