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Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors (CROSBI ID 217952)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Balog, Marta ; Miljanović, Milan ; Blažetić, Senka ; Labak, Irena ; Ivić, Vedrana ; Viljetić, Barbara ; Borbely, Attila ; Papp, Zoltán ; Blažeković, Robert ; Vari, Sandor G et al. Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors // Croatian medical journal, 56 (2015), 2; 104-113. doi: 10.3325/cmj.2015.56.104

Podaci o odgovornosti

Balog, Marta ; Miljanović, Milan ; Blažetić, Senka ; Labak, Irena ; Ivić, Vedrana ; Viljetić, Barbara ; Borbely, Attila ; Papp, Zoltán ; Blažeković, Robert ; Vari, Sandor G ; Fagyas, Miklós ; Heffer, Marija

engleski

Sex-specific chronic stress response at the level of adrenal gland modified sexual hormone and leptin receptors

Aim was to compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress. Forty six 16-week-old Sprague- Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ERβ), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed. Body weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ERβ receptors in comparison to control group (P=0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P=0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P=0.033). Chronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to an increase in testosterone receptor in females and decrease in estrogen receptor in males.

Adrenal gland; sexual hormone receptors; leptin receptors

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Podaci o izdanju

56 (2)

2015.

104-113

objavljeno

0353-9504

10.3325/cmj.2015.56.104

Povezanost rada

Temeljne medicinske znanosti, Biologija

Poveznice
Indeksiranost