engleski

Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis

Tumor development, promotion and ability to spread depend greatly on tumor microenvironment. Rapid growth accompanied by inadequate angiogenesis is the reason why most solid tumors contain hypoxic regions. Activation of hypoxia signaling pathways stimulates neoangiogenesis, alters tumor metabolism, promotes a more aggressive tumor behavior and significantly affects its responsiveness to therapy. Growing amount of evidence suggest that hypoxia induces transcription of tumor promoting genes leading to increased tumor cell proliferation and metastatic potential. Improved understanding of molecular pathways will enable establishment of useful prognostic and predictive factors, along with more effective treatment options.

hypoxia; solid tumor; angiogenesis; tumor microenvironment; gene expression; progression; metastasis; resistance to treatment

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