engleski

Effect of pre-transplant dialysis modality on kidney transplantation outcome – a single center experience

This study examined associations of pretransplant dialysis modality with post-transplant outcomes in kidney transplant recipients (RTRs). We retrospectively examined the 24-year data of 519 patients who underwent a renal transplantation from January 1990 to January 2014. Fifty-seven RTRs were on peritoneal dialysis (PD) prior to transplantation, while 462 RTRs were treated with haemodialysis (HD) prior to transplantation. Delayed graft function (DGF) was defined as dialysis required in the first seven days after transplantation. There was no significant difference due to gender between the two groups of RTRs, while PD-RTRs were significantly older in comparison to the HD-RTRs (55.1±11.5vs.49.6±13.9 years ; p=0.003). The mean duration of renal replacement therapy prior to transplantation was longer in the HD-RTRs group of patients (48.6±55.9vs.34±39.1 months ; p=0.05). The most common etiology of chronic kidney disease in both groups of patients was glomerulonephritis. We observed no significant differences between the groups with regard to donor age, donor gender and human leukocyte antigen mismatching. The proportion of living donor transplants in the HD-RTRs group of patients was higher than in the PD-RTRs group of patients (15.6%vs.5.3%). There was no significant difference due to incidence of DGF between two groups of patients (34.6%vs.33.3%). During the first year after transplantation 31 HD-RTRs loss their grafts. The main reason for graft loss were acute rejection crisis (3%) and surgical complications (2.8%). On the other hand, 13 PD-RTRs loss their graft during the first year after transplantation. In comparison to the HD-RTRs group of patients, graft thrombosis was the most common cause of graft lose in PD-RTRs group of patients (14%vs.0.4%). There were no significant differences in the patients and graft survival between the PD-RTRs and HD-RTRs groups of patients after one-year of follow-up (Long-rank test ; p=0.662). Pretransplant dialysis modality has no significant impact on patients and allograft outcome.

hemodialysis; peritoneal dialysis; transplantation

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