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Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium


Šegota, Suzana; Vojta, Danijela; Kendziora, Dania; Ahmed, Ishtiaq; Fruk, Ljiljana; Baranović, Goran
Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium // The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 119 (2015), 16; 5208-5219 doi:10.1021/acs.jpcb.5b00898 (međunarodna recenzija, članak, znanstveni)


Naslov
Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium

Autori
Šegota, Suzana ; Vojta, Danijela ; Kendziora, Dania ; Ahmed, Ishtiaq ; Fruk, Ljiljana ; Baranović, Goran

Izvornik
The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical (1520-6106) 119 (2015), 16; 5208-5219

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Clustering; Force spectroscopy; IR spectroscopy; Nanomechanics; Nanoparticles

Sažetak
The interactions between hydrophobic or semihydrophobic gold and silver nanoparticles (NPs) and a dimyristoylphosphatidylcholine (DMPC) bilayer as a model cell membrane in two ionic solutions result in the structural reorganization within the bilayer manifested as locally increased nanomechanical compaction in the vicinity of NP clusters as well as changed overall thermotropic properties. The effects of NP surface charge and hydrophobicity were examined using AFM imaging, force spectroscopy and IR spectroscopy. The NP clustering occurred during hydration process of dry films containing both the DMPC molecules and the NPs by the mechanism in which the number of bilayer deformations was reduced by NP clustering. The force spectroscopy showed increased bilayer density around (semi)hydrophobic NP clusters and thus locally increased lateral compaction of the bilayer. The strengthening effect was observed for both the silver and the gold NPs in a high ionic strength solution such as seawater, while it was absent under physiological conditions. The local lipid rearrangement induces the longrange lipid reorganization resulting in the bilayer phase transition shifting toward lower or higher temperatures depending on the solution ionic strength (at the most by −1.0 °C in phosphate buffered saline and at the most by +0.5 °C in seawater).

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA


Projekt / tema
098-0982904-2927 - Makrociklički ligandi, strukturne promjene otopina i molekularne spektroskopije (Goran Baranović, )
098-0982934-2744 - Površinske sile na atomskoj skali u istraživanju mora i nanotehnologiji (Vesna Svetličić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Šegota, Suzana; Vojta, Danijela; Kendziora, Dania; Ahmed, Ishtiaq; Fruk, Ljiljana; Baranović, Goran
Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium // The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 119 (2015), 16; 5208-5219 doi:10.1021/acs.jpcb.5b00898 (međunarodna recenzija, članak, znanstveni)
Šegota, S., Vojta, D., Kendziora, D., Ahmed, I., Fruk, L. & Baranović, G. (2015) Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical, 119 (16), 5208-5219 doi:10.1021/acs.jpcb.5b00898.
@article{article, year = {2015}, pages = {5208-5219}, DOI = {10.1021/acs.jpcb.5b00898}, keywords = {Clustering, Force spectroscopy, IR spectroscopy, Nanomechanics, Nanoparticles}, journal = {The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces and biophysical}, doi = {10.1021/acs.jpcb.5b00898}, volume = {119}, number = {16}, issn = {1520-6106}, title = {Ligand-Dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium}, keyword = {Clustering, Force spectroscopy, IR spectroscopy, Nanomechanics, Nanoparticles} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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