Multilayer clustering: Biomarker driven segmentation of Alzheimer's disease patient population (CROSBI ID 623416)
Prilog sa skupa u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Gamberger, Dragan ; Ženko, Bernard ; Mitelpunkt, Alexis ; Lavrač, Nada
engleski
Multilayer clustering: Biomarker driven segmentation of Alzheimer's disease patient population
Identification of biomarkers for the Alzheimer's disease is a challenge and a very difficult task both for medical research and data analysis. In this work we present results obtained by application of a novel clustering tool. The goal is to identify subpopulations of the Alzheimer's disease (AD) patients that are homogeneous in respect of available clinical and biological descriptors. The result presents a segmentation of the Alzheimer's disease patient population and it may be expected that within each subpopulation separately it will be easier to identify connections between clinical and biological descriptors. Through the evaluation of the obtained clusters with AD subpopulations it has been noticed that for two of them relevant biological measurements (whole brain volume and intracerebral volume) change in opposite directions. If this observation is actually true it would mean that the diagnosed severe dementia problems are results of different physiological processes. The observation may have substantial consequences for medical research and clinical trial design. The used clustering methodology may be interesting also for other medical and biological domains.
Data clustering; Alzheimer's disease; Biomarker identification
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Podaci o prilogu
134-145.
2015.
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objavljeno
Podaci o matičnoj publikaciji
Lecture notes in computer science
Ortuno, Francisco ; Rojas, Ignacio
Heidelberg: Springer
978-3-319-16482-3
0302-9743
Podaci o skupu
International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015)
predavanje
15.04.2015-17.04.2015
Granada, Španjolska