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Pregled bibliografske jedinice broj: 758623

Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients


Vučić Lovrenčić, Marijana; Pibernik-Okanović, Mirjana, Ajduković, Dea; Šekerija, Mario; Hermanns, Norbert
Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients // Diabetologia 2014 ; 57 (Supplement 1)
Beč, Austrija, 2014. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 758623 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients

Autori
Vučić Lovrenčić, Marijana ; Pibernik-Okanović, Mirjana, Ajduković, Dea ; Šekerija, Mario ; Hermanns, Norbert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Diabetologia 2014 ; 57 (Supplement 1) / - , 2014

Skup
50th EASD Annual Meeting, Vienna, Austria,

Mjesto i datum
Beč, Austrija, 15-19.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diabetes; depression; oxidative damage; inflammation

Sažetak
Background and aims: Processes of inflammation and oxidative damage are insufficiently clarified in diabetic patients suffering subsyndromal depression. This study was aimed to examine one-year changes in inflammatory- and pro-oxidative biomarkers in patients who were treated for elevated depressive symptoms that do not reach criteria for clinical depression. Materials and methods: A randomized controlled comparison of two behavioural interventions for subsyndromal depression – six-week lasting psychoeducation and physical exercise, and a control condition consisting of brief diabetes re-education -was performed in the sample of 209 type 2 diabetic patients with subsyndromal depression (aged 57±6 yrs, 54% female, diabetes duration: 11±8 yrs, 32% insulin treated, HbA1c: 7.3%±1.2 and BMI: 30±5 kg/m2). Clinical depression was excluded by using a Structured Clinical Interview for the DSM-IV Axis I disorders. A level of depressive symptoms, endogenous inflammatory markers (leukocytes, CRP), indicators of antioxidative capacity (myeloperoxidase index [MPXI], plasma uric acid), and markers of oxidative damage (sialic acid, urinary 8-OH-deoxyguanosine [u-8- OH-dG] ) were assessed at baseline, and after six-and twelve months. Repeated measures ANOVA’s were employed to determine within- and between-group differences in depressive symptoms and the measured biomarkers at follow- ups. Results: Participants in the psychoeducational- , physical exercise and the control group improved equally in depressive symptoms from baseline to 12-month follow-up (time- versus time x group effect ; F= 12.51 p<.0001 η2=0.07 and F=0.609 p=0.656 η2=0.007 respectively). Total leukocytes significantly decreased in all three groups (7.7±1.8 to 7.1±1.6 F=15.72 p<.0001 η2=.119) as did sialic acid (2.1±0.3 to 1.8±0.3 F=135.67 p<.0001 η2=0.323) and u-8-OH-dG (1.1±0.5 to 0.99±0.5 F=10.66 p<.0001 η2=0.06). No within- and between group changes were registered with respect to CRP and MPXI. Uric acid increased significantly during one year in all three groups (295.1±84.9 to 315.8±84.4 F=12.53 p<.0001 η2=0.07) with time effects being greater in women compared to men (η2=0.13 versus η2=0.03). Conclusion: Lowering depressive symptoms in subsyndromally depressed type 2 diabetic patients was found to be associated with long- term improvements in biomarkers of inflammation and oxidative stress. Treatment of even mild depressive symptoms may have favourable clinical implications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
045-0450961-0959 - Učinci psihoedukacije na ishode liječenja u depresivnih dijabetičkih bolesnika (Pibernik-Okanović, Mirjana, MZOS ) ( POIROT)
045-1191348-0139 - Biomolekule guanidinskog tipa u šećernoj bolesti (Vučić Lovrenčić, Marijana, MZOS ) ( POIROT)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac


Citiraj ovu publikaciju:

Vučić Lovrenčić, Marijana; Pibernik-Okanović, Mirjana, Ajduković, Dea; Šekerija, Mario; Hermanns, Norbert
Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients // Diabetologia 2014 ; 57 (Supplement 1)
Beč, Austrija, 2014. (poster, međunarodna recenzija, sažetak, znanstveni)
Vučić Lovrenčić, M., Pibernik-Okanović, Mirjana, Ajduković, Dea, Šekerija, M. & Hermanns, N. (2014) Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients. U: Diabetologia 2014 ; 57 (Supplement 1).
@article{article, year = {2014}, keywords = {diabetes, depression, oxidative damage, inflammation}, title = {Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients}, keyword = {diabetes, depression, oxidative damage, inflammation}, publisherplace = {Be\v{c}, Austrija} }
@article{article, year = {2014}, keywords = {diabetes, depression, oxidative damage, inflammation}, title = {Improvement in depressive symptoms is associated with reduced markers of inflammation and oxidative damage in type 2 diabetic patients}, keyword = {diabetes, depression, oxidative damage, inflammation}, publisherplace = {Be\v{c}, Austrija} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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