Charged Amphiphylic Ligands of Nanoparticles Increase Lateral Compaction of Membranes. Nanomechanical and Thermotropic Study of Model Lipid Membranes in High Ionic Strength Solutions (CROSBI ID 623156)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Šegota, Suzana ; Vojta, Danijela ; Kendziora, Dania ; Ahmed, Ishtiaq ; Fruk, Ljiljana ; Baranović, Goran
engleski
Charged Amphiphylic Ligands of Nanoparticles Increase Lateral Compaction of Membranes. Nanomechanical and Thermotropic Study of Model Lipid Membranes in High Ionic Strength Solutions
The research of the nanoparticle (NP) delivery systems and the use of NPs both for diagnostic and therapeutic purposes have created a need for understanding the complex interactions of NPs with cells. Membrane-NP interactions are of crucial importance both for the cell uptake and toxicological investigations. For that reason, lipids that are the cell membrane building blocks, have been used as simplified model systems to study not only the mechanical properties of the membranes and their interactions with different molecular species, but also their structural organization in, for example, marine ecosystems, which are particularly sensitive to the toxicological environmental effects[1]. The presence of hydrophobic NPs embedded within a lipid bilayer, can lead to rearrangement of lipid nolecules by modifying interactions amongst the lipd headgroups and/or acyl tails. Therefore, research towards the examination of interaction of NP within lipid membranes using transmission infrared spectroscopy and force spectroscopy (FS) have been undertaken. Our research deciphered interactions of hydrophobic NP with model membranes through their delicate response in physiological and seawater environment. Functionality of the NP has been related to the organisation and fluidity of the model lipid membrane. The formation of lipid/NP assemblies containing hydrophobically modified NPs showed specific effects on the later compaction of the supported lipid bilayers arround NPs in both media.
Clustering ; Force spectroscopy ; IR spectroscopy ; Nanomechanics ; Nanoparticles
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Podaci o prilogu
1-1.
2014.
objavljeno
Podaci o matičnoj publikaciji
9th Christmas Biophysics workshop
Zagreb: Croatian Biophysical Society, December 2014.
Podaci o skupu
9th Christmas Biophysics workshop
predavanje
15.12.2014-16.12.2014
Buzet, Hrvatska