engleski

Infectious bursal disease outbreak: experimental infection of broilers with evidence of significantly reduced body weight gain and interference with transcription for interferon

A recent outbreak of infectious bursal disease (IBD) in vaccinated broilers in Croatia with generally no increased mortality, watery diarrhoea and significantly reduced body weight gains is described. Experimental infection of fully susceptible 30-day-old broilers with IBD virus (IBDV) isolated from affected chickens resulted in no mortality and mild clinical signs but body weight gains were significantly reduced (52.9 grams and 83.6 grams per day in susceptible and immune birds, respectively), during the two weeks after contact infection. Rapid seroconversion was noted in unvaccinated birds. Induced transcription of interferon alpha and gamma of susceptible broilers was significantly reduced on the 7th and 14th day after exposure to isolated virus, whereas induction in broilers vaccinated for IBDV was not reduced. Infection of 4-week-old SPF chickens with the virus resulted in severe disease with 60% mortality.

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