Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia (CROSBI ID 217394)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dajak, Slavica ; Krstić, Jelena ; Körmöczi, Gunther ; Dogić, Vesna ; Burilović, Vedrana
engleski
Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia
D variants, collectively called DEL, express trace amounts of D antigen which is considered to be serologically detectable only by adsorption-elution techniques. We detected six cases of DEL phenotype by indirect antiglobulin test, in Dalmatia County of Croatia by routine serological testing of D antigen of new blood donors. RH genotyping found that all six donors carry allele RHD(M295I), RH genotype CcDdee. D antigen densities of D variants were very low, between 26 and 44 D antigens per red blood cell. The frequency of D variants detected by IAT allele RHD(M295I) was 1:272 in D negative donors. Obviously, DEL phenotype is more common in some parts of European population than initially thought. In conclusion, our routine serological testing of D antigen can detect extremely weak D antigen, even RBCs with DEL phenotype and antigen density as low as 26 D antigens per RBC.
Genotyping RHD; Indirect antiglobulin test; Weak D variants
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Podaci o izdanju
50 (2)
2014.
210-213
objavljeno
1473-0502
10.1016/j.transci.2014.01.019
Povezanost rada
Kliničke medicinske znanosti