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Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia (CROSBI ID 217394)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dajak, Slavica ; Krstić, Jelena ; Körmöczi, Gunther ; Dogić, Vesna ; Burilović, Vedrana Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia // Transfusion and apheresis science, 50 (2014), 2; 210-213. doi: 10.1016/j.transci.2014.01.019

Podaci o odgovornosti

Dajak, Slavica ; Krstić, Jelena ; Körmöczi, Gunther ; Dogić, Vesna ; Burilović, Vedrana

engleski

Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia

D variants, collectively called DEL, express trace amounts of D antigen which is considered to be serologically detectable only by adsorption-elution techniques. We detected six cases of DEL phenotype by indirect antiglobulin test, in Dalmatia County of Croatia by routine serological testing of D antigen of new blood donors. RH genotyping found that all six donors carry allele RHD(M295I), RH genotype CcDdee. D antigen densities of D variants were very low, between 26 and 44 D antigens per red blood cell. The frequency of D variants detected by IAT allele RHD(M295I) was 1:272 in D negative donors. Obviously, DEL phenotype is more common in some parts of European population than initially thought. In conclusion, our routine serological testing of D antigen can detect extremely weak D antigen, even RBCs with DEL phenotype and antigen density as low as 26 D antigens per RBC.

Genotyping RHD; Indirect antiglobulin test; Weak D variants

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Podaci o izdanju

50 (2)

2014.

210-213

objavljeno

1473-0502

10.1016/j.transci.2014.01.019

Povezanost rada

Kliničke medicinske znanosti

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