engleski

One-pot click synthesis of 1,2,3-triazole-embedded unsaturated uracil derivatives and hybrids of 1,5- and 2,5-disubstituted tetrazoles and pyrimidines

Novel conformationally restricted pyrimidine derivatives with a 1, 2, 3-triazolyl scaffold bound via Z- and E-2-butenyl spacers were prepared by Cu(I)-catalyzed click chemistry via a one-pot, multi-step reaction under microwave irradiation, while 1, 5- and 2, 5-disubstituted tetrazoles were synthesized by convenient, environmentally friendly click synthesis and subsequently by N- alkylation of 5-substituted 1H-tetrazoles. Among all the tested compounds, the N-1, N-3- disubstituted olefinic uracil derivative showed the highest antiproliferative effects.

1, 2, 3-Triazoles ; 1, 5- and 2, 5-disubstituted tetrazoles ; Antitumor activity ; Click chemistry ; One-pot

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