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Pregled bibliografske jedinice broj: 756566

One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines


Krištafor, Svjetlana; Bistrović, Andrea; Plavec, Janez; Makuc, Damjan; Martinović, Tamara; Kraljević Pavelić, Sandra; Raić-Malić, Silvana
One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines // Tetrahedron letters, 56 (2015), 10; 1222-1228 doi:10.1016/j.tetlet.2015.01.152 (međunarodna recenzija, članak, znanstveni)


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Naslov
One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines

Autori
Krištafor, Svjetlana ; Bistrović, Andrea ; Plavec, Janez ; Makuc, Damjan ; Martinović, Tamara ; Kraljević Pavelić, Sandra ; Raić-Malić, Silvana

Izvornik
Tetrahedron letters (0040-4039) 56 (2015), 10; 1222-1228

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1 ; 2 ; 3-Triazoles ; 1 ; 5- and 2 ; 5-disubstituted tetrazoles ; Antitumor activity ; Click chemistry ; One-pot

Sažetak
Novel conformationally restricted pyrimidine derivatives with a 1, 2, 3-triazolyl scaffold bound via Z- and E-2-butenyl spacers were prepared by Cu(I)-catalyzed click chemistry via a one-pot, multi-step reaction under microwave irradiation, while 1, 5- and 2, 5-disubstituted tetrazoles were synthesized by convenient, environmentally friendly click synthesis and subsequently by N- alkylation of 5-substituted 1H-tetrazoles. Among all the tested compounds, the N-1, N-3- disubstituted olefinic uracil derivative showed the highest antiproliferative effects.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
125-0982464-2925 - Razvoj i primjena novih molekula u pozitron-emisijskoj tomografiji (PET) (Raić-Malić, Silvana, MZOS ) ( POIROT)
HRZZ-IP-2013-11-5596 - Sinteza i citostatska ispitivanja biblioteke novih dušikovih heterocikla (SCIENcENTRY) (Raić-Malić, Silvana, HRZZ - 2013-11) ( POIROT)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Krištafor, Svjetlana; Bistrović, Andrea; Plavec, Janez; Makuc, Damjan; Martinović, Tamara; Kraljević Pavelić, Sandra; Raić-Malić, Silvana
One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines // Tetrahedron letters, 56 (2015), 10; 1222-1228 doi:10.1016/j.tetlet.2015.01.152 (međunarodna recenzija, članak, znanstveni)
Krištafor, S., Bistrović, A., Plavec, J., Makuc, D., Martinović, T., Kraljević Pavelić, S. & Raić-Malić, S. (2015) One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines. Tetrahedron letters, 56 (10), 1222-1228 doi:10.1016/j.tetlet.2015.01.152.
@article{article, year = {2015}, pages = {1222-1228}, DOI = {10.1016/j.tetlet.2015.01.152}, keywords = {1, 2, 3-Triazoles, 1, 5- and 2, 5-disubstituted tetrazoles, Antitumor activity, Click chemistry, One-pot}, journal = {Tetrahedron letters}, doi = {10.1016/j.tetlet.2015.01.152}, volume = {56}, number = {10}, issn = {0040-4039}, title = {One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines}, keyword = {1, 2, 3-Triazoles, 1, 5- and 2, 5-disubstituted tetrazoles, Antitumor activity, Click chemistry, One-pot} }
@article{article, year = {2015}, pages = {1222-1228}, DOI = {10.1016/j.tetlet.2015.01.152}, keywords = {1, 2, 3-Triazoles, 1, 5- and 2, 5-disubstituted tetrazoles, Antitumor activity, Click chemistry, One-pot}, journal = {Tetrahedron letters}, doi = {10.1016/j.tetlet.2015.01.152}, volume = {56}, number = {10}, issn = {0040-4039}, title = {One-pot click synthesis of 1, 2, 3-triazole- embedded unsaturated uracil derivatives and hybrids of 1, 5- and 2, 5-disubstituted tetrazoles and pyrimidines}, keyword = {1, 2, 3-Triazoles, 1, 5- and 2, 5-disubstituted tetrazoles, Antitumor activity, Click chemistry, One-pot} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka::


  • AGRICOLA
  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • Chemical Engineering and Biotechnology Abstracts
  • Current Biotechnology Abstracts
  • MEDLINE


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