Radioprotective effects of synthetised adamantyl-thienylcyclidines (CROSBI ID 482660)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Ferle-Vidović, Ana ; Jukić, Ivan ; Škare, Danko
engleski
Radioprotective effects of synthetised adamantyl-thienylcyclidines
Several adamantyl derivatives of thienylcyclidine 1-(1(2-thyenylcyclohexyl)) piperidine (TCP), were sythetised and characterised (Ad-TCP I-IV). Their biological activity was evaluated by in vitro testing of their effect on proliferative and reproductive ability of human tumor strain and non-malignant mouse fobroblasts in culture. These effect were compared with those of thyenylcyclidine (TCP). We also tested them on cultured cells, for their radioprotective effect after ionising irradiation. The results with non-malignant mouse fibroblasts and human tumour cells, show that the piperidine derivative of adamantyl-thienylcyclidine (Ad-TCP II) has rather outstanding radioprotective properties. This derivative revealed significant radioprotection at all survival levels, depending on the malignant or non-malignant origin of the cells, and it was significantly more evident on mouse fibroblasts then on human tumor cells. These effect were compared with those of thienylciycidine.
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Podaci o prilogu
54-x.
2001.
objavljeno
Podaci o matičnoj publikaciji
Obelić, B. ; Ranogajec-Komor, M. ; Miljanić, S. ; Krajcar Bronić
Zagreb: Croatian Radiation Protection Association
Podaci o skupu
IRPA Regional Congress on Radiation Protection in Central Europe: Radiation protection and Health
poster
20.05.2001-25.05.2001
Dubrovnik, Hrvatska