Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe (CROSBI ID 216923)
Prilog u časopisu | Pismo (znanstveno) | međunarodna recenzija
Podaci o odgovornosti
Glunčić, Matko ; Maghelli, Nicola ; Krull, Alexander ; Krstić, Vladimir ; Ramunno-Johnson, Damien ; Pavin, Nenad ; Tolić, Iva M. ;
engleski
Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe
In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe ; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.
Kinesin-8; Centering; Microtubule
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Podaci o izdanju
114
2015.
078103-1-078103-5
objavljeno
0031-9007
10.1103/PhysRevLett.114.078103