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Pregled bibliografske jedinice broj: 754687

Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide


Baretić, Maja; Pavlić-Renar, Ivana; Aganović, Izet
Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide // Diabetologia Croatica, 42 (2013), 3; 67-71 (međunarodna recenzija, članak, znanstveni)


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Naslov
Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide

Autori
Baretić, Maja ; Pavlić-Renar, Ivana ; Aganović, Izet

Izvornik
Diabetologia Croatica (0351-0042) 42 (2013), 3; 67-71

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
exenatide; blood pressure; weight loss

Sažetak
Exenatide treatment is related to lower blood pressure. It is explained by different pathophysiological pathways. We explored the dynamics of blood pressure and weight loss during one-year therapy with exenatide. Forty-nine type 2 diabetic patients previously treated with a combination of metformin and sulfonylurea were included in this open-label, intention to treat study. Five mg of exenatide was administered twice daily for 4 weeks, and then 10 mg twice daily as adjunctive therapy to the pre-existing treatment. Patients in whom antihypertensive therapy was modified were excluded from analysis. At the end of 52 weeks, systolic blood pressure decreased significantly, with a 4.65 mm Hg reduction (P=0.008582) in exenatide treated patients. There was a positive correlation between body weight and systolic blood pressure drop (Pearson coefficient 0.675254). The interesting blood pressure curve could have relied on various antihypertensive mechanisms of exenatide: drop of blood pressure at first 16 weeks could have been connected with natriuresis and the second one with later vasodilatation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinički bolnički centar Zagreb

Profili:

Avatar Url Maja Baretić (autor)

Avatar Url Ivana Pavlić-Renar (autor)

Avatar Url Izet Aganović (autor)


Citiraj ovu publikaciju:

Baretić, Maja; Pavlić-Renar, Ivana; Aganović, Izet
Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide // Diabetologia Croatica, 42 (2013), 3; 67-71 (međunarodna recenzija, članak, znanstveni)
Baretić, M., Pavlić-Renar, I. & Aganović, I. (2013) Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide. Diabetologia Croatica, 42 (3), 67-71.
@article{article, year = {2013}, pages = {67-71}, keywords = {exenatide, blood pressure, weight loss}, journal = {Diabetologia Croatica}, volume = {42}, number = {3}, issn = {0351-0042}, title = {Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide}, keyword = {exenatide, blood pressure, weight loss} }
@article{article, year = {2013}, pages = {67-71}, keywords = {exenatide, blood pressure, weight loss}, journal = {Diabetologia Croatica}, volume = {42}, number = {3}, issn = {0351-0042}, title = {Association of blood pressure and body weight decline during one-year treatment with the incretin analogue exenatide}, keyword = {exenatide, blood pressure, weight loss} }

Časopis indeksira:


  • Scopus


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  • EMBASE , Scopus, BIOSIS, Thompson Reuters master journal list





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