Napredna pretraga

Pregled bibliografske jedinice broj: 753982

Surgical Treatment of Prolactinomas – Our Experience


Gnjidić, Živko; Kudelić, Nenad; Sajko, Tomislav; Malenica, Maša; Stipić, Darko; Rotim, Krešimir
Surgical Treatment of Prolactinomas – Our Experience // Collegium antropologicum, 38 (2014), 2; 571-576 (međunarodna recenzija, članak, znanstveni)


Naslov
Surgical Treatment of Prolactinomas – Our Experience

Autori
Gnjidić, Živko ; Kudelić, Nenad ; Sajko, Tomislav ; Malenica, Maša ; Stipić, Darko ; Rotim, Krešimir

Izvornik
Collegium antropologicum (0350-6134) 38 (2014), 2; 571-576

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Prolactinoma ; transsphenoidal ; microsurgical ; dopamine agonists ; hyperprolactinemia ; prolactinoma surgery

Sažetak
The dilemma of whether to apply surgical or drug treatment to prolactinomas has been ongoing for the past 30 years. The aim of this study is to compare the early postoperative values of prolactin (PRL) in two groups of patients with prolactinomas: those who underwent primary surgical-treatment, and those who underwent surgery after a dopamine agonist (DA) therapy. We present the results of surgical treatment on a series of 161 patients with prolactinomas. Surgery was the primary treatment in 65 patients, while 96 patients had surgery following a long-term treatment with a DA. All surgically treated prolactinomas were operated in the standard transsphenoidal, microsurgical approach. The criteria for hyperprolactinemia remission was a PRL level under 25 ng/ml. Early normalization of PRL was achieved in 92% of those patients who underwent primary surgical-treatment, yet it was achieved in only 42% of patients who were operated on after receiving a long-term drug treatment with a DA. The highest prevalence of postoperative normalization of PRL was achieved in a group of patients with microadenomas who were primarily operated on (98%). The worst results in postoperative normalization of PRL were found in the group of patients with macroadenomas who received a long-term drug treatment with a DA first. These results show our surgical experience in treating prolactinomas. Using surgical treatment, the best clinical outcome was acieved with microprolactinomas and intrasellar, well-confined macroprolactinomas. Nevertheless, we stress the need of an individualized approach and recommend treatment in multidisciplinary centres for pituitary diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
KBC "Sestre Milosrdnice",
Opća bolnica Varaždin