Serotonin and apoptosis: studies on rat lymphocytes (CROSBI ID 93757)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Štefulj, Jasminka ; Jakopec, Sanjica ; Osmak, Maja ; Jernej, Branimir
engleski
Serotonin and apoptosis: studies on rat lymphocytes
Objective: The apoptogenic potential of serotonin (5-hydroxytryptamine, 5HT) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. Methods: Apoptosis was measured either by morphological criteria (experiment 1) or by flow cytometry (experiment 2). Results: In both experiments serotonin, in concentration producing half-maximal inhibition of lymphocyte proliferation, has significantly increased basal level of apoptosis. Conclusion: Apoptotic mechanism should be taken into account when considering immunoinhibition induced by serotonin.
apoptosis; serotonin; 5HT; lymphocytes; proliferation; rat
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija