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Pregled bibliografske jedinice broj: 75358

Serotonin and apoptosis: studies on rat lymphocytes


Štefulj, Jasminka; Jakopec, Sanjica; Osmak, Maja; Jernej, Branimir
Serotonin and apoptosis: studies on rat lymphocytes // Neuroimmunomodulation, 10 (2002), 3; 132-133 (međunarodna recenzija, članak, znanstveni)


Naslov
Serotonin and apoptosis: studies on rat lymphocytes

Autori
Štefulj, Jasminka ; Jakopec, Sanjica ; Osmak, Maja ; Jernej, Branimir

Izvornik
Neuroimmunomodulation (1021-7401) 10 (2002), 3; 132-133

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Apoptosis; serotonin; 5HT; lymphocytes; proliferation; rat

Sažetak
Objective: The apoptogenic potential of serotonin (5-hydroxytryptamine, 5HT) on mitogen-stimulated lymphocytes was studied in primary cultures of rat spleen cells, in two sets of experiments. Methods: Apoptosis was measured either by morphological criteria (experiment 1) or by flow cytometry (experiment 2). Results: In both experiments serotonin, in concentration producing half-maximal inhibition of lymphocyte proliferation, has significantly increased basal level of apoptosis. Conclusion: Apoptotic mechanism should be taken into account when considering immunoinhibition induced by serotonin.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098076
0098081

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE