Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Assessment of autozygosity in Nellore cows (Bos indicus) through high-density SNP genotypes (CROSBI ID 216715)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Balbo Zavarez, Ludmilla ; Utsunomiya, Yuri Tani ; Santana Carmo, Adriana ; Neves, HH ; Carvalheiro, Roberto ; Ferenčaković, Maja ; Pérez O’Brien, Ana Maria ; Čurik, Ino ; Cole, John B. ; Van Tassell, Curtis et al. Assessment of autozygosity in Nellore cows (Bos indicus) through high-density SNP genotypes // Frontiers in genetics, 6 (2015), 5; 1-8. doi: 10.3389/fgene.2015.00005

Podaci o odgovornosti

Balbo Zavarez, Ludmilla ; Utsunomiya, Yuri Tani ; Santana Carmo, Adriana ; Neves, HH ; Carvalheiro, Roberto ; Ferenčaković, Maja ; Pérez O’Brien, Ana Maria ; Čurik, Ino ; Cole, John B. ; Van Tassell, Curtis ; Vinicius Silva, Marcus ; Stewart Sonstegard, Tad ; Sölkner, Johann ; Garcia, Jose Fernando

engleski

Assessment of autozygosity in Nellore cows (Bos indicus) through high-density SNP genotypes

The use of relatively low numbers of sires in cattle breeding programs, particularly on those for carcass and weight traits in Nellore beef cattle (Bos indicus) in Brazil, has always raised concerns about inbreeding, which affects conservation of genetic resources and sustainability of this breed. Here, we investigated the distribution of autozygosity levels based on runs of homozygosity (ROH) in a sample of 1, 278 Nellore cows, genotyped for over 777, 000 SNPs. We found ROH segments larger than 10 Mb in over 70% of the samples, representing signatures most likely related to the recent massive use of few sires. However, the average genome coverage by ROH (>1 Mb) was lower than previously reported for other cattle breeds (4.58%). In spite of 99.98% of the SNPs being included within a ROH in at least one individual, only 19.37% of the markers were encompassed by common ROH, suggesting that the ongoing selection for weight, carcass and reproductive traits in this population is too recent to have produced selection signatures in the form of ROH. Three short-range highly prevalent ROH autosomal hotspots (occurring in over 50% of the samples) were observed, indicating candidate regions most likely under selection since before the foundation of Brazilian Nellore cattle. The putative signatures of selection on chromosomes 4, 7, and 12 may be involved in resistance to infectious diseases and fertility, and should be subject of future investigation.

Bos indicus ; runs of homozygosity ; selection ; cattle ; fertility ; disease resistance

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

6 (5)

2015.

1-8

objavljeno

1664-8021

10.3389/fgene.2015.00005

Povezanost rada

Biotehnologija, Veterinarska medicina

Poveznice
Indeksiranost