engleski

Mechanochemical Ritter reaction : a rapid approach to functionalized amides at room temperature

A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment, utilizing a Brønsted acid catalyst. Its general application has been verified through a substrate screening investigation comprising a wide range of functionalized nitriles, as well as secondary and tertiary alcohols.

Mechanochemistry; Ritter reaction; Amides; Organocatalysis; Mild conditions

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