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Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread


Lemmermann, N.; Krmpotić, Astrid; Podlech, J.; Brizić, Ilija; Prager, A.; Adler, H.; Karbach, A.; Wu, Y.; Jonjić, Stipan; Reddehase, M.J.; Adler, B.
Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread // Plos pathogens, 11 (2015), 2; e1004640-1 doi:10.1371/journal.ppat.1004640 (međunarodna recenzija, članak, znanstveni)


Naslov
Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread

Autori
Lemmermann, N. ; Krmpotić, Astrid ; Podlech, J. ; Brizić, Ilija ; Prager, A. ; Adler, H. ; Karbach, A. ; Wu, Y. ; Jonjić, Stipan ; Reddehase, M.J. ; Adler, B.

Izvornik
Plos pathogens (1553-7366) 11 (2015), 2; E1004640-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytomegalovirus ; gH/FL complexes ; gO ; MCK-2 ; herpesviruses

Sažetak
Herpesviruses form different gH/gL virion envelope glycoprotein complexes that serve as entry complexes for mediating viral cell-type tropism in vitro ; their roles in vivo, however, remained speculative and can be addressed experimentally only in animal models. For murine cytomegalovirus two alternative gH/gL complexes, gH/gL/gO and gH/gL/MCK-2, have been identified. A limitation of studies on viral tropism in vivo has been the difficulty in distinguishing between infection initiation by viral entry into first-hit target cells and subsequent cell-to-cell spread within tissues. As a new strategy to dissect these two events, we used a gO-transcomplemented ΔgO mutant for providing the gH/gL/gO complex selectively for the initial entry step, while progeny virions lack gO in subsequent rounds of infection. Whereas gH/gL/gO proved to be critical for establishing infection by efficient entry into diverse cell types, including liver macrophages, endothelial cells, and hepatocytes, it was dispensable for intra-tissue spread. Notably, the salivary glands, the source of virus for host-to-host transmission, represent an exception in that entry into virus-producing cells did not strictly depend on either the gH/gL/gO or the gH/gL/MCK-2 complex. Only if both complexes were absent in gO and MCK-2 double-knockout virus, in vivo infection was abolished at all sites

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Astrid Krmpotić (autor)

Avatar Url Stipan Jonjić (autor)

Avatar Url Ilija Brizić (autor)

Citiraj ovu publikaciju

Lemmermann, N.; Krmpotić, Astrid; Podlech, J.; Brizić, Ilija; Prager, A.; Adler, H.; Karbach, A.; Wu, Y.; Jonjić, Stipan; Reddehase, M.J.; Adler, B.
Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread // Plos pathogens, 11 (2015), 2; e1004640-1 doi:10.1371/journal.ppat.1004640 (međunarodna recenzija, članak, znanstveni)
Lemmermann, N., Krmpotić, A., Podlech, J., Brizić, I., Prager, A., Adler, H., Karbach, A., Wu, Y., Jonjić, S., Reddehase, M. & Adler, B. (2015) Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread. Plos pathogens, 11 (2), e1004640-1 doi:10.1371/journal.ppat.1004640.
@article{article, year = {2015}, pages = {e1004640-1-e1004640-}, DOI = {10.1371/journal.ppat.1004640}, keywords = {cytomegalovirus, gH/FL complexes, gO, MCK-2, herpesviruses}, journal = {Plos pathogens}, doi = {10.1371/journal.ppat.1004640}, volume = {11}, number = {2}, issn = {1553-7366}, title = {Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread}, keyword = {cytomegalovirus, gH/FL complexes, gO, MCK-2, herpesviruses} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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