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Synthesis and Conformational Study of Bioconjugates Derived from 1-Acetyl-1'-aminoferrocene and α-Amino Acids

1, 1'-Disubstituted ferrocene conjugates present useful and efficient bioorganometallic constraint design to reduce the conformational flexibility of small peptides. In this study we present the first systematic conformational analysis of nonsymmetric ferrocene peptidomimetics (Boc-AA-NH-Fn-COMe ; Boc = tert-butoxycarbonyl ; AA = Gly, L-Ala, L-Val ; Fn = 1, 1-ferrocenylene) and their monosubstituted analogues(Boc-AA-NH-Fc ; Fc = ferrocenyl ; AA = Gly, L-Ala, L-Val).

Conformation analysis; Density functional calculations; Bioinorganic chemistry; Peptidomimetics; Hydrogen bonds; Circular dichroism

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