Could chloramphenicol be used against ESKAPE pathogens? A review of in vitro data in the literature from the 21st century (CROSBI ID 215736)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Čivljak, Rok ; Giannella, Maddalena ; Di Bella, Stefano ; Petrosillo, Nicola
engleski
Could chloramphenicol be used against ESKAPE pathogens? A review of in vitro data in the literature from the 21st century
The widespread use of antibiotics has been associated with the emergence of antimicrobial resistance among bacteria. ‘ESKAPE’ (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acintobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) pathogens play a major role in the rapidly changing scenario of antimicrobial resistance in the 21st century. Chloramphenicol is a broad spectrum antibiotic that was abandoned in developed countries due to its association with fatal aplastic anemia. However, it is still widely used in the developing world. In light of the emerging problem of multi-drug resistant pathogens, its role should be reassessed. Our paper reviews in vitro data on the activity of chloramphenicol against ESKAPE pathogens. Susceptibility patterns for Gram-positives were good, although less favorable for Gram-negatives. However, in combination with colistin, chloramphenicol was found to have synergistic activity. The risk-benefit related to chloramphenicol toxicity has not been analyzed. Therefore, extra precautions should be taken when prescribing this agent.
antimicrobials; chloramphenicol; combination therapy; ESKAPE pathogens; resistance
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Podaci o izdanju
12 (2)
2014.
249-264
objavljeno
1478-7210
10.1586/14787210.2014.878647
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita