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In vitro and in vivo effect of natural clinoptilolite on malignant tumors (CROSBI ID 482485)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Poljak-Blaži, Marija ; Katić, Maša ; Kralj, Marijeta ; Žarković, Neven ; Marotti, Tanja ; Bošnjak, Berislav ; Šverko, Višnja ; Balog, Tihomir ; Pavelić, Krešimir In vitro and in vivo effect of natural clinoptilolite on malignant tumors // Proceedings of the 13th International Zeolite Conference "Zeolites and Mesoporous Materials at the Dawn of the 21st Century" ; Studies in surface science and catalysis ; Vol. 135 / Galarneau, A. ; di Renzo, F. ; Fajula, F. et al. (ur.). Amsterdam: Elsevier, 2001. str. 374-374

Podaci o odgovornosti

Poljak-Blaži, Marija ; Katić, Maša ; Kralj, Marijeta ; Žarković, Neven ; Marotti, Tanja ; Bošnjak, Berislav ; Šverko, Višnja ; Balog, Tihomir ; Pavelić, Krešimir

engleski

In vitro and in vivo effect of natural clinoptilolite on malignant tumors

Many biochemical processes are closely related to ion change, adsorption and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide, they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. In vitro experiments showed inhibition of tumor cell proliferation as well as MZ to be the possible scavenger of HNE. After i.p. application of MZ, the number of peritoneal macrophages was increased as well as their production of oxide anion. NO generation was totally abolished. At te same time translocationof p65 subunit of NF-kapaB in spleen cells was observed. Thus, here we report anticancer effect of MZ in vitro and immunostimulatory effect in vivo. We also propose possible mechanism of its action in vivo.

natural clinoptilolite; tumor

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Podaci o prilogu

374-374.

2001.

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objavljeno

978-0-444-50238-4

Podaci o matičnoj publikaciji

Proceedings of the 13th International Zeolite Conference "Zeolites and Mesoporous Materials at the Dawn of the 21st Century" ; Studies in surface science and catalysis ; Vol. 135

Galarneau, A. ; di Renzo, F. ; Fajula, F. ; Vedrine, J.

Amsterdam: Elsevier

Podaci o skupu

International Zeolite Conference (13 ; 2001)

poster

08.07.2001-13.07.2001

Montpellier, Francuska

Povezanost rada

Temeljne medicinske znanosti