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Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white

The distribution of sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after administration of a SMM/TMP combination in laying hens in doses of 8 g L-1 and 12 g L-1 in drinking water for 7 days. The SMM concentration reached maximal levels on day 2 of the post-treatment period for both doses (μg kg- 1): 5919.8 and 9453.3 in yolk ; 4830.5 and 6050.1 in white, in doses 1 and 2, respectively. Significant differences in the SMM and TMP concentrations between yolk and white in post treatment period were found. SMM dropped below the LOD (1.9 μg kg-1) in yolk after day 16 and 19 for doses 1 and 2. TMP reached maximal levels on day 3 after drug administration for doses 1 and 2 (μg kg- 1): 6521.3 and 7329.2 in yolk, 1369.5 and 1539.1 in white. TMP residues were measured above LOD (0.3 μg kg-1) in yolk for both doses on day 37 post- treatment.

Sulfamonomethoxine; Trimethoprim; Elimination; Laying hens; Egg; Yolk; White; LC-MS/MS

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