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Pregled bibliografske jedinice broj: 748507

Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast


Stuparević, Igor; Mosrin-Huaman, Christine; Hervouet-Coste, Nadege; Remenarić, Mateja; Rahmouni, Rachid
Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast // The Journal of biological chemistry, 288 (2013), 44; 31816-31829 doi:10.1074/jbc.M113.491290 (međunarodna recenzija, članak, znanstveni)


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Naslov
Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast

Autori
Stuparević, Igor ; Mosrin-Huaman, Christine ; Hervouet-Coste, Nadege ; Remenarić, Mateja ; Rahmouni, Rachid

Izvornik
The Journal of biological chemistry (0021-9258) 288 (2013), 44; 31816-31829

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mRNA; mRNA decay; RNA; RNA metabolism; RNA processing

Sažetak
The cotranscriptional mRNA processing and packaging reactions that lead to the formation of export-competent messenger ribonucleoprotein particles (mRNPs) are under the surveillance of quality control steps. Aberrant mRNPs resulting from faulty events are retained in the nucleus with ensuing elimination of their mRNA component. The molecular mechanisms by which the surveillance system recognizes defective mRNPs and stimulates their destruction by the RNA degradation machinery are still not completely elucidated. Using an experimental approach in which mRNP formation in yeast is disturbed by the action of the bacterial Rho helicase, we have shown previously that the targeting of Rho-induced aberrant mRNPs is mediated by Rrp6p, which is recruited cotranscriptionally in association with Nrd1p following Rho action. Here we investigated the specific involvement in this quality control process of different cofactors associated with the nuclear RNA degradation machinery. We show that, in addition to the main hydrolytic action of the exonuclease Rrp6p, the cofactors Rrp47p, Mpp6p as well as the Trf-Air-Mtr4 polyadenylation (TRAMP) components Trf4p, Trf5p, and Air2p contribute significantly by stimulating the degradation process upon their cotranscriptional recruitment. Trf4p and Trf5p are apparently recruited in two distinct TRAMP complexes that both contain Air2p as component. Surprisingly, Rrp47p appears to play an important role in mutual protein stabilization with Rrp6p, which highlights a close association between the two partners. Together, our results provide an integrated view of how different cofactors of the RNA degradation machinery cooperate to target and eliminate aberrant mRNPs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija



POVEZANOST RADA


Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Profili:

Avatar Url Igor Stuparević (autor)

Poveznice na cjeloviti tekst rada:

doi www.jbc.org

Citiraj ovu publikaciju:

Stuparević, Igor; Mosrin-Huaman, Christine; Hervouet-Coste, Nadege; Remenarić, Mateja; Rahmouni, Rachid
Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast // The Journal of biological chemistry, 288 (2013), 44; 31816-31829 doi:10.1074/jbc.M113.491290 (međunarodna recenzija, članak, znanstveni)
Stuparević, I., Mosrin-Huaman, C., Hervouet-Coste, N., Remenarić, M. & Rahmouni, R. (2013) Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast. The Journal of biological chemistry, 288 (44), 31816-31829 doi:10.1074/jbc.M113.491290.
@article{article, year = {2013}, pages = {31816-31829}, DOI = {10.1074/jbc.M113.491290}, keywords = {mRNA, mRNA decay, RNA, RNA metabolism, RNA processing}, journal = {The Journal of biological chemistry}, doi = {10.1074/jbc.M113.491290}, volume = {288}, number = {44}, issn = {0021-9258}, title = {Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast}, keyword = {mRNA, mRNA decay, RNA, RNA metabolism, RNA processing} }
@article{article, year = {2013}, pages = {31816-31829}, DOI = {10.1074/jbc.M113.491290}, keywords = {mRNA, mRNA decay, RNA, RNA metabolism, RNA processing}, journal = {The Journal of biological chemistry}, doi = {10.1074/jbc.M113.491290}, volume = {288}, number = {44}, issn = {0021-9258}, title = {Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast}, keyword = {mRNA, mRNA decay, RNA, RNA metabolism, RNA processing} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • MEDLINE


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