engleski

The role of negative pressure wound therapy in patients with kidney transplantation

Kidney transplantation is the best treatment modality for patients with end-stage renal disease. Immunosupression is needed to prevent graft rejection. Some immunosupressive drugs, as steroids and mTOR inhibitors, has negative impact on wound healing. Wound healing is impaired in patients with kidney transplantation. In the recent time negative pressure wound therapy become important technique of the wound management. We present a two patients with problems with wound healing in the early posttransplant period. In both patients immunosupressive regime was based on tacrolimus, mycophenolate mophetil and high-dose corticosteroids with anti IL-2 induction therapy. Postoperatively, the wound become inflamated and opened. Negative pressure wound therapy was successfully applied to aid wound healing. The duration of treatment was 2 and 3 weeks respectively. After that period wound becomes improved and closed with secondary stiches. After secondary closing of the wound posttransplant course was uneventful in both patients. Now, 1 and 3 years after transplantation they have well functionized kidney. According to our limited experience negative pressure wound therapy is feasible and effective treatment of infected wounds after kidney transplantation.

kidney transplantation

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