Molecular structures of new ciprofloxacin derivatives (CROSBI ID 93565)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Banić-Tomišić, Zrinka ; Kujundžić, Nedjeljko ; Bukvić Krajačić, Mirjana ; Višnjevac, Aleksandar ; Kojić-Prodić, Biserka
engleski
Molecular structures of new ciprofloxacin derivatives
Two new ciprofloxacin derivatives from the fluoroquinolone family, 7-chloro-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-quinoline-3-methylcarbamate and 5-cyclopropyl-7-(4-ethyl-1-piperazine-1-yl)-8-fluoro-2, 5-dihydro-pyrazolo[4, 3-c]quinolin-3-on, were synthesized, tested for antibacterial activity, crystallised and their molecular and crystal structures determined. In vitro tests revealed their lower activity than for ciprofloxacin. Characteristic structural features of these compounds are comparable to data for other known fluoroquinolones. Bicyclic quinoline ring is planar in both compounds ; carbamate side chain and five-membered pyrazolo ring are almost coplanar with it. A piperazinyl ring exhibits a chair conformation. Pyrazolo derivative crystallises as solvate with 1.5 water molecules per a quinolone molecule. In the crystal structure of the pyrazolo derivative donor and acceptor funcionalities form hydrogen bonded dimers that are connected into an infinite pattern using hydrogen bonds through water molecules.
Fluoro-quinolones; Synthesis; Antimicrobial activity X-ray structure; Hydrogen bonds; C-H F intramolecular interaction
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano