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Pregled bibliografske jedinice broj: 744988

Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital


Bubonja-Šonje, Marina; Matovina, Mihaela; Škrobonja, Ivana; Bedenić, Branka; Abram, Maja
Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital // Microbial drug resistance-mechanisms epidemiology and disease, 21 (2015), 3; 261-269 doi:10.1089/mdr.2014.0172 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 744988 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital

Autori
Bubonja-Šonje, Marina ; Matovina, Mihaela ; Škrobonja, Ivana ; Bedenić, Branka ; Abram, Maja

Izvornik
Microbial drug resistance-mechanisms epidemiology and disease (1076-6294) 21 (2015), 3; 261-269

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antimicrobial resistance; carbapenems; efflux pumps; porins; Pseudomonas aeruginosa

Sažetak
Pseudomonas aeruginosa is opportunistic pathogen, one of the leading causes of nosocomial infections such as pneumonia, urinary tract infections, and bacteraemia. The bacterial resistance to structurally unrelated antibiotics and its spread within hospitals limits the efficient antimicrobial options and patients' outcome. Carbapenems are important agents for the therapy of infections due to multidrug-resistant (MDR) P. aeruginosa, hence the development of carbapenem resistance severely hampers effective therapeutic options. The aim of this investigation was to examine mechanisms of carbapenem resistance and genomic diversity in carbapenem-resistant MDR strains of P. aeruginosa which caused an outbreak among patients in Clinical Hospital Rijeka. Most of the isolates showed decreased expression of porin that is important for the entry of carbapenems (oprD). Overexpression of MexAB-OprM, MexCD-OprJ, and MexEF-OprN efflux systems was observed in many of the isolates. Production of metallo-beta-lactamases (MBL) was not detected. Typing by pulsed-field gel electrophoresis discriminated the isolates into five clusters. The clonal distribution of the strains was related to the location of hospital departments where the isolates were collected, which implies that most of the infections were caused by spread of the epidemic strains within the hospital.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Rad je financiran uz potporu Sveučilišta u Rijeci.



POVEZANOST RADA


Projekti:
108-1080114-0015 - Mehanizmi rezistencije na antibiotike u Gram-negativnih bakterija (Bedenić, Branka, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

Bubonja-Šonje, Marina; Matovina, Mihaela; Škrobonja, Ivana; Bedenić, Branka; Abram, Maja
Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital // Microbial drug resistance-mechanisms epidemiology and disease, 21 (2015), 3; 261-269 doi:10.1089/mdr.2014.0172 (međunarodna recenzija, članak, znanstveni)
Bubonja-Šonje, M., Matovina, M., Škrobonja, I., Bedenić, B. & Abram, M. (2015) Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital. Microbial drug resistance-mechanisms epidemiology and disease, 21 (3), 261-269 doi:10.1089/mdr.2014.0172.
@article{article, year = {2015}, pages = {261-269}, DOI = {10.1089/mdr.2014.0172}, keywords = {antimicrobial resistance, carbapenems, efflux pumps, porins, Pseudomonas aeruginosa}, journal = {Microbial drug resistance-mechanisms epidemiology and disease}, doi = {10.1089/mdr.2014.0172}, volume = {21}, number = {3}, issn = {1076-6294}, title = {Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital}, keyword = {antimicrobial resistance, carbapenems, efflux pumps, porins, Pseudomonas aeruginosa} }
@article{article, year = {2015}, pages = {261-269}, DOI = {10.1089/mdr.2014.0172}, keywords = {antimicrobial resistance, carbapenems, efflux pumps, porins, Pseudomonas aeruginosa}, journal = {Microbial drug resistance-mechanisms epidemiology and disease}, doi = {10.1089/mdr.2014.0172}, volume = {21}, number = {3}, issn = {1076-6294}, title = {Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital}, keyword = {antimicrobial resistance, carbapenems, efflux pumps, porins, Pseudomonas aeruginosa} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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