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Clinical and pathophysiological significance of antineutrophil autoantibodies (ANCA)in vasculitis (CROSBI ID 53365)

Prilog u knjizi | ostalo

Kozmar, Ana ; Malenica, Branko Clinical and pathophysiological significance of antineutrophil autoantibodies (ANCA)in vasculitis // Lung in non-pulmonary and systemic disease / Peroš-Golubičić, Tatjana (ur.). Zagreb: Medicinska naklada, 2013. str. 367-381

Podaci o odgovornosti

Kozmar, Ana ; Malenica, Branko

engleski

Clinical and pathophysiological significance of antineutrophil autoantibodies (ANCA)in vasculitis

Antineutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 or myeloperoxidase are strongly associated with ANCA-associated vasculitides-Wegener s granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome. They produce either perinuclear or cytoplasmic fluorescence pattern on ethanol-fixed neutrophils by indirect immunofluorescence. ANCA are useful tools for diagnosing and monitoring primary small vessel vasculitides. ANCA testing is a highly sensitive and specific test for making a diagnosis of Wegener s granulomatosis, microscopic polyangiitis or Curg-Strauss syndrome. In these patients, ANCA titers are related to disease activity and a rise in titer may precede a clinical relapse. Several findings indicate that ANCA and their target antigens may be implicated in the pathogenesis of primary small vessel vasculitides. This evidence comes from clinical observations, in vitro and in vivo experiments.

ANCA, PR3, MPO, primary small vessel vasculitides

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Podaci o prilogu

367-381.

objavljeno

Podaci o knjizi

Lung in non-pulmonary and systemic disease

Peroš-Golubičić, Tatjana

Zagreb: Medicinska naklada

2013.

978-953-176-643-2

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti