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Pregled bibliografske jedinice broj: 74407

Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas


Osmak, Maja; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez
Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas // Neoplasma, 48 (2001), 6; 462-467 (međunarodna recenzija, članak, znanstveni)


Naslov
Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas

Autori
Osmak, Maja ; Babić, Damir ; Abramić, Marija ; Miličić, Duško ; Vrhovec, Ivan ; Škrk, Janez

Izvornik
Neoplasma (0028-2685) 48 (2001), 6; 462-467

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
endometrial carcinoma; urokinase plasminogen activator; plasminogen activator inhibitor type 1; plasminogen activator inhibitor type 2

Sažetak
The clinical determination of proteases which are involved in carcinogenesis, invasion and metastasis may contribute to the detection of the early stage of disease, and to the prognostic assessment of patients with the cancer. The aim of the present study was to determine the level of urokinase plasminogen activator (uPA), plasminogen activator inhibitor type 1 (PAI-1) and plasminogen activator inhibitor type 2 (PAI-2) in normal and malignant tissues of corpus uteri and to evaluate the possible correlation with clinical and histopathological prognostic factors. UPA, PA-I and PAI-2 were determined by the ELISA assay in tissue cytosol of matched pair samples from 27 patients with endometrial carcinoma. Results show that significantly higher levels of these proteins were found in malignant than in normal tissue samples (uPA ; 1.266 versus 0.633 ng/mg protein, PAI-1: 4.468 versus 1.958 ng/mg protein, and PAI-2:3.428 versus 0.483 ng/ml protein). The levels of uPA and PAI-1 did not correlate with clinical staging or pathohistological grading. However, in tumor tissues with clinical stages II and III, myometrial invasion > 50%, and lymphovascular invasion, increased levels of PAI-2 were determined. Our results indicate that components of the plasminogen activation cascade are up-regulated in endometrial cancer and suggest the role of PAI-2 in determining invasive potential of endometrial carcinomas.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
00980705
00981008
108097

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Damir Babić (autor)

Avatar Url Duško Miličić (autor)

Avatar Url Maja Osmak (autor)

Avatar Url Marija Abramić (autor)

Citiraj ovu publikaciju

Osmak, Maja; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez
Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas // Neoplasma, 48 (2001), 6; 462-467 (međunarodna recenzija, članak, znanstveni)
Osmak, M., Babić, D., Abramić, M., Miličić, D., Vrhovec, I. & Škrk, J. (2001) Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas. Neoplasma, 48 (6), 462-467.
@article{article, year = {2001}, pages = {462-467}, keywords = {endometrial carcinoma, urokinase plasminogen activator, plasminogen activator inhibitor type 1, plasminogen activator inhibitor type 2}, journal = {Neoplasma}, volume = {48}, number = {6}, issn = {0028-2685}, title = {Plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas}, keyword = {endometrial carcinoma, urokinase plasminogen activator, plasminogen activator inhibitor type 1, plasminogen activator inhibitor type 2} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Excerpta Medica
  • Index Medicus