engleski

The analysis of enzymes matrix metalloproteinases- 2 and 9 in atherosclerosis

The members of the matrix metalloproteinase (MMP) family play a crucial role in angiogenesis and vascular remodeling and are involved in the pathogenesis of vascular diseases such as atherosclerosis, varicose veins, hypertension, abdominal aortic aneurysm, preeclampsia, etc. Alterations in vascular tone are usually a result of changeable endothelial cell function, as well as increasing activity of neurohormonal stimuli or altered sensitivity of vascular smooth muscle. Chronic changes in vascular function lead to structural changes in the blood vessel architecture. The aim of our study was to examine the values of enzyme matrix metalloproteinase-9 in urine in patients with atherosclerosis of carotid arteries, undergoing surgery, and compare to controls (healthy volunteers). Patients and methods: we analyzed 40 patients with atherosclerosis who were undergoing the surgical procedure. The method of enzyme immunoassay (ELISA) was used to determine enzymes expression of matrix metalloproteinase-2 and 9 (MMP-2 and 9). Statistical data were Calculated using computer program Statistica 7.1. Results: The patients with atherosclerosis had a statistically significantly increased level of MMP-2 and 9 in the urine in comparison with healthy volunteers. Conclusion: Our data has showed a large increase in the enzyme MMP-2 and 9 in the urine of atherosclerotic patients, which can be an easy marker for the monitoring of the development of atherosclerosis.

atherosclerosis ; enzymes matrix metalloproteinases-2 and 9

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