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Pregled bibliografske jedinice broj: 742597

Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.


Perić, Magdalena; Bošnjak, Zinka; Šarkanj, Bojan; Barbić, Jerko; Antolović-Požgain, Arlen; Ružman, Nataša; Roksandić-Križan, Ivana; Vuković, Dubravka
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia. // Archives of virology, 160 (2015), 1; 297-304 doi:10.1007/s00705-014-2283-0 (međunarodna recenzija, članak, znanstveni)


Naslov
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.

Autori
Perić, Magdalena ; Bošnjak, Zinka ; Šarkanj, Bojan ; Barbić, Jerko ; Antolović-Požgain, Arlen ; Ružman, Nataša ; Roksandić-Križan, Ivana ; Vuković, Dubravka

Izvornik
Archives of virology (0304-8608) 160 (2015), 1; 297-304

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hepatitis C virus; HCV genotype; TLR2; TLR4; gene polymorphism; antiviral therapy

Sažetak
Chronic infection with hepatitis C virus (HCV) is caused by an inadequate immune response. Experimental data suggest that the impaired activation of Toll-like receptors (TLRs) 2 and 4 contributes to chronic infection. We assessed the distribution of three single-nucleotide polymorphisms (SNPs) in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly/Thr399Ile) genes in individuals from north-east Croatia and their effect on the outcome of antiviral therapy. The study consisted of 60 chronically infected patients and 40 healthy subjects. TLR polymorphisms were determined by the PCR-based melting curve analysis. HCV genotyping was performed using the Linear Array Hepatitis C Virus Genotyping Test. Thirty-three patients were treated with standard interferon and ribavirin therapy, and their viral load was evaluated at weeks 28 and 53 after the beginning of therapy. The majority of chronic infections were caused by genotype 1 (77%), followed by genotypes 3 (15%) and 4 (7%). Patients with genotype 1 had higher viral loads than patients infected with other genotypes (P = 0.0428). Healthy individuals and patients with chronic infection had similar frequencies of TLR2-Arg753Gln and TLR4-Asp299Gly/Thr399Ile SNPs. Heterozygous and homozygous TLR4- Asp299Gly/Thr399Ile polymorphisms correlated with higher viral loads and delayed responses to antiviral therapy. We have provided the first evidence that TLR4 polymorphisms influence the success of antiviral therapy in our region. This suggests that therapeutic strategies should be adjusted not only according to HCV genotype but also to individual TLR polymorphism(s).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Jerko Barbić, )

Ustanove
Prehrambeno-tehnološki fakultet, Osijek,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Perić, Magdalena; Bošnjak, Zinka; Šarkanj, Bojan; Barbić, Jerko; Antolović-Požgain, Arlen; Ružman, Nataša; Roksandić-Križan, Ivana; Vuković, Dubravka
Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia. // Archives of virology, 160 (2015), 1; 297-304 doi:10.1007/s00705-014-2283-0 (međunarodna recenzija, članak, znanstveni)
Perić, M., Bošnjak, Z., Šarkanj, B., Barbić, J., Antolović-Požgain, A., Ružman, N., Roksandić-Križan, I. & Vuković, D. (2015) Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.. Archives of virology, 160 (1), 297-304 doi:10.1007/s00705-014-2283-0.
@article{article, year = {2015}, pages = {297-304}, DOI = {10.1007/s00705-014-2283-0}, keywords = {hepatitis C virus, HCV genotype, TLR2, TLR4, gene polymorphism, antiviral therapy}, journal = {Archives of virology}, doi = {10.1007/s00705-014-2283-0}, volume = {160}, number = {1}, issn = {0304-8608}, title = {Polymorphisms of Toll-like receptors 2 and 4 in chronically infected hepatitis C patients from north-east Croatia.}, keyword = {hepatitis C virus, HCV genotype, TLR2, TLR4, gene polymorphism, antiviral therapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • AGRICOLA
  • ASFA: Aquatic Science and Fisheries Abstracts
  • BIOSIS Previews (Biological Abstracts)
  • CAB Abstracts
  • FSTA: Food Science and Technology Abstracts
  • MEDLINE


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