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ACTIVATION OF IMMUNITY IN HYPERTENSION

Objective Aim of the study is to determine: Toll like receptor 4 (TLR4) expression on monocytes and the level of interleukin 17 (IL 17) in patients’ serum, whether there is correlation between TLR4 expression and IL 17 level, if the type of the used hypertension class influences TLR4 expression and IL 17 level and if hypertension duration contributes to TLR4 expression or IL 17 level. Design and Methods There have been 50 patients included in the study and 33 of them have unregulated hypertension, 17 have regulated hypertension (control group). The blood pressure was measured with Omron M6 Comfort phygmomanometer, on both hands three times. The relevant value was the mean value, measured on the hand which showed higher pressure values. The increased blood pressure was the one over 140/90 mmHg. The patients had their IL 17 serum level determined with ELISA method and the TLR 4 expressions on monocytes from periphery blood applying free flow cytometry. Results Our study did not show differences in TLR4 expression between two patients' group. However, in the patient group with unregulated hypertension inter quartal range was significantly higher than in the control group. There is no significant difference in IL 17 between two groups. The expression of TLR4 is much lower in the patients who were prescribed beta blockers. The level of IL 17 is significantly higher in the patients who use diuretics. In the group of the patients with unregulated hypertension, there was a significant correlation between level of IL 17 and hypertension duration, but in the group with well regulated hypertension there was no correlation. There was no correlation between TLR4 expression and level of IL 17. Conclusion Long term unregulated hypertension leads to the activation of specific immunity response and IL 17 can be a marker of unregulated hypertension duration. The results suggest also that the choice of prescribed anti-hypertension drugs can modify the activity of immunity response.

Hypertension; immunity; TLR4; IL-17

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