Naslov
Follicular fluid anti-Müllerian hormone : a predictive marker of fertilization capacity of MII oocytes
(Follicular fluid anti-Mullerian hormone: a predictive marker of fertilization capacity of MII oocytes)

Autori
Tramišak Milaković, Tamara ; Panić Horvat, Linda ; Čavlović, Kristina ; Smiljan Severinski, Neda ; Vlašić, Hrvoje ; Vlastelić, Ivan ; Ljiljak, Dejan ; Radojčić Badovinac, Anđelka

Izvornik
Archives of gynecology and obstetrics (0932-0067) 291 (2015), 3; 681-687

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antimilerov hormon ; kvaliteta zametka ; kapacitet fertilizacije ; folikularna tekućina ; ICSI ; kvaliteta oocita
(Antimullerian hormone ; embryo quality ; fertilization capacity ; follicular fluid ; ICSI ; oocyte quality)

Sažetak
The present study aimed to correlate anti-Mu¨llerian hormone (AMH) levels in follicular fluid (FF) with oocyte maturity stages, morphological quality of metaphase II (MII) oocyte and fertilization capacity of MII oocytes. A total of 92 infertile women undergoing controlled ovarian stimulation and intracytoplasmic sperminjection were analyzed. Patients were divided into two groups according to age: <35 years (n = 43) and >/= 35 years (n = 49). An FF sample was obtained from a single dominant follicle in each patient for a total of 92 follicular fluid samples analyzed. AMH levels in serum and follicular fluid were measured by enzyme-linked immunosorbent assay. Mature MII oocytes, zygotes, and embryos were assessed for morphological quality. Serum AMH levels were significantly higher in patients aged <35 years. No correlation was observedbetween FF AMH level and oocyte maturation stages or morphological quality of MII oocyte.Significantly lowerFF AMH levels were observed in fertilized MII oocytes than in non-fertilized MII oocytes in patients aged <35 years (2.56 ± 2.0 ng/ml vs. 4.81 ± 4.14 ng/ml ; p = 0.032). The present study revealed no correlation between FF AMH and oocyte maturity stage or morphological quality of MII oocyte. However, FF AMH might be a predictive marker for fertilization capacity of MII oocytes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA