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izvor podataka: crosbi

Effect of adamantyl compounds on dynamics of spin labelled multilamellar liposomes (CROSBI ID 214048)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mirosavljević, Krunoslav ; Matković, Marija ; Milnarić-Majerski, Kata ; Nothig-Laslo, Vesna Effect of adamantyl compounds on dynamics of spin labelled multilamellar liposomes // Croatica chemica acta, 87 (2014), 3; 249-253. doi: 10.5562/cca2399

Podaci o odgovornosti

Mirosavljević, Krunoslav ; Matković, Marija ; Milnarić-Majerski, Kata ; Nothig-Laslo, Vesna

engleski

Effect of adamantyl compounds on dynamics of spin labelled multilamellar liposomes

Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride (compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dynamics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggested that both adamantyl compounds influenced molecular motions in the interfacial region of the liposome. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamellar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydrophobic core as well.

adamantyl compounds ; drug transport ; drug interactions ; physicochemical properties ; spin labelling ; ESR ; spectroscopy ; liposomes ; phospholipids

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Podaci o izdanju

87 (3)

2014.

249-253

objavljeno

0011-1643

10.5562/cca2399

Povezanost rada

Kemija

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