Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor (CROSBI ID 214026)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Milković, Lidija ; Čipak Gašparović, Ana ; Žarković, Neven Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor // Free radical research, 49 (2015), 7; 850-860. doi: 10.3109/10715762.2014.999056

Podaci o odgovornosti

Milković, Lidija ; Čipak Gašparović, Ana ; Žarković, Neven

engleski

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor

The reactive aldehyde 4-hydroxynonenal (HNE) is major bioactive marker of lipid peroxidation generated under oxidative stress from polyunsaturated fatty acids. Biomedical significance of HNE was first revealed in pathogenesis of various degenerative and malignant diseases. Thus, HNE was considered for decades only as cytotoxic molecule, “second toxic messenger of free radicals” responsible for numerous undesirable consequences of oxidative stress. However, the increase of knowledge on physiology of redox signaling revealed also desirable, physiological roles of HNE, especially in the field of cellular signaling pathways regulating proliferation, differentiation, and apoptosis. These pluripotent effects of HNE can be explained by its concentration-dependent interactions with the cytokine networks and complex cellular antioxidant systems also showing cell and tissue specificities. Therefore, this paper gives a comprehensive, yet short overview on HNE as pluripotent growth-regulating factor.

cell proliferation; growth regulation; hormesis; lipid peroxidation; oxidative stress

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

49 (7)

2015.

850-860

objavljeno

1071-5762

10.3109/10715762.2014.999056

Povezanost rada

nije evidentirano

Poveznice
Indeksiranost