engleski

Molecular and cellular approach in the study of antioxidant/prooxidant properties of Micromeria croatica (Pers.) Schott

Phytochemical composition and antioxidant activity of three wild populations of endemic Illyric-Balcanic species Micromeria croatica (Pers.) Schott have been evaluated with respect to plant organ and growing location. Multivariate analysis (PCA) was performed to visualize (dis-)similarity among samples and identify correlations between phytochemical variables that explain the most variability. The tested leaf extract from locality Bačić kuk exhibited protective effects against ROS- induced damage of DNA and inhibition of lipid peroxidation, while it caused oxidative degradation of protein in the BSA assay at higher concentrations. This extract also exhibited cytotoxic activity and facilitated the formation of ROS in the HEp2 cell line, in a dose-dependent manner.

antioxidant ; cytotoxicity ; Micromeria croatica (Pers.) Schott. ; polyphenols ; prooxidant

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