engleski

Patients with schizophrenia taking typical or atypical antipsychotics: evaluating symptoms with Brief Psychiatry rating Scale

Objective: To evaluate changes in symptoms in patients with schizophrenia taking typical and atypical antipsychotics, using Brief Psychiatry Rating Scale (BPRS). Methods: BPRS was used in order to evaluate changes in symptoms in 96 patients vvith paranoid schizophrenia (49 male, 47 female, mean age/years 37.6) according to DSM-IV-TR criteria. Previous 10 inclusion in our study, ali patients were treated vvith typical or atypical antipsychotics for a period of at least three months. Out of total number, 43 patients vvere treated vvith typical and 53 vvith atypi-cal antipsychotics. The first assessment (baseline) vvas made upon the inclusion. The other assessments vvere made every three months during one year. Results vvere statistically analysed using methods of descriptive statistics and chi-square test. Statistical significance vvas set to p<0.05. During investigation there vvere 9 cases of therapy discontinuation due to side effects (restless-ness, tremor) in the group of patients treated vvith typical antipsy-chotics, and 6 cases in the group of patients treated vvith atypical antipsychotics (sedation, hyperprolactinemia, vveight gain). The patients vvho discontinued the therapy vvere assessed on the last day of therapy, and their results vvere added to the results of other patients from the group. Results: At baseline, there vvas no significant difference betvveen tvvo groups of patients on the BPRS items. After six months of continuous treatment, patients treated vvith atypical antipsychotics scored significantly better in BPRS items regarding emotional vvithdravval, depressive mood and uncooperativeness. After one year of continuous treatment, patients treated vvith atypical antipsychotics scored significantly better in BPRS items regarding emotional vvithdravval, depressive mood, uncooperativeness, and blunted affect. Conclusion: Results indicate superiority of atypical over typical antipsy-chotics in reducing negative and general symptoms of schizophrenia measured by BPRS.

shizophrenia; tpical antipsychotics; aypical antipsychotics

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