engleski

Tissue Engineering and Regenerative Orthopaedics (TERO)

According to Greek mythology, Prometheus’ liver grew back nightly after it was removed each day by an eagle as punishment for giving fire to mankind. Hence, the concept of tissue and organ regeneration is not new. Combinations of the three major components of regenerative medicine: cells, biomaterials and bioactive molecules have created a new paradigm of future therapeutic options for most species. Orthopaedic injuries are a source of enhanced misery and economic burden, because tissues like cartilage, meniscus, and intra-articular ligaments do not heal. Even the bone repair, which normally occurs spontaneously, can fail. The regeneration of orthopaedic tissues requires cells, morphogenetic signals, scaffolds, and an appropriate mechanical environment. The last Special Issue of International Orthopaedics covering regeneration of bone, cartilage and tendon was edited by us in 2007 [1]. Since then, the field of tissue engineering and skeletal regeneration has progressed by development of novel biomaterials, devices, growth factor carriers and their use in patients.

regenerative medicine; cells; biomaterials; bioactive molecules

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