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Pregled bibliografske jedinice broj: 738205

Nme family of proteins—clues from simple animals


Ćetković, Helena; Perina, Dragutin; Harcet, Matija; Mikoč, Andreja; Herak Bosnar, Maja
Nme family of proteins—clues from simple animals // Naunyn-Schmiedeberg's archives of pharmacology, 388 (2015), 2; 133-142 doi:10.1007/s00210-014-1017-x (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Nme family of proteins—clues from simple animals

Autori
Ćetković, Helena ; Perina, Dragutin ; Harcet, Matija ; Mikoč, Andreja ; Herak Bosnar, Maja

Izvornik
Naunyn-Schmiedeberg's archives of pharmacology (0028-1298) 388 (2015), 2; 133-142

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Non-bilaterian metazoans; Porifera; NDPK; Nm23; Nme

Sažetak
Nucleoside-diphosphate kinases (Nme/Nm23/ NDPK) are evolutionarily conserved enzymes involved in many biological processes in vertebrates. The biochemical mechanisms of these processes are still largely unknown. The Nme family consists of ten members in humans of which Nme1/2 have been extensively studied in the context of carcinogenesis, especially metastasis formation. Lately, it has been proven that the majority of genes linked to human diseases were already present in species distantly related to humans. Most of cancer-related protein domains appeared during the two main evolutionary transitions—the emergence of unicellular eukaryotes and the transition to multicellular metazoans. In spite of these recent insights, current knowledge about cancer and status of cancer-related genes in simple animals is limited. One possible way of studying human diseases relies on analyzing genes/ proteins that cause a certain disease by using model organism that represent the evolutionary level at which these genes have emerged. Therefore, basalmetazoans are ideal model organisms for gaining a clearer picture how characteristics and functions of Nme genes changed in the transition to multicellularity and increasing complexity in animals, giving us exciting new evidence of their possible functions in potential pathological conditions in humans.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2513 - Uloga gena nm23 u karcinomu pločastog epitela usne šupljine (Maja Herak-Bosnar, )
098-0982913-2874 - Geni i genomi: struktura, funkcija i evolucija (Helena Ćetković, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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