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Treatment with haloperidol and changes in glucose values in patients with schizophrenia

Results: Patient, 39 years old, with diagnosis of schizophrenia, was in psychiatric treatment for the past 20 years. The patient's compli-ance with previous oral antipsychotic therapy was poor and for that reason she was treated with haloperidol depot during period of 5 years. The patient occasionally had ideas of reference, but with such treatment she was able to function in her social activities and at work. At control examination, the patient reported often being thirsty and also reported frequent urination. The laboratory exami-nation and examination of specialist of internal medicine were advised. Results of laboratory examination showed glucose value above the reference range. In the same time, there was no change in patient's body weight. Also, there was no change in patient's diet. Treatment with haloperidol was discontinued and treatment with fluphenazine was initiated, again as depot injection, because of poor compliance with oral antipsychotic therapy. The patient responded well to such therapy, she was able to function in her social activities and at work, and values of glucose gradually returned to previous values (within reference range).Conclusion: Laboratory examination showed glucose value above the reference range in the patient who was treated with haloperidol depot ; after switching to fluphenazine depot values of glucose gradually returned to previous values (within reference range). Policy of full disclosure: None.

glucose; patient; schizophrenia; haloperidol

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