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A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure


Radić Stojković, Marijana; Piotrowski, Patryciusz; Schmuck, Carsten; Piantanida, Ivo
A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure // Organic & biomolecular chemistry, 13 (2015), 1629-1633 doi:10.1039/c4ob02169j (međunarodna recenzija, članak, znanstveni)


Naslov
A Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure

Autori
Radić Stojković, Marijana ; Piotrowski, Patryciusz ; Schmuck, Carsten ; Piantanida, Ivo

Izvornik
Organic & biomolecular chemistry (1477-0520) 13 (2015); 1629-1633

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Guanidiniocarbonyl-pyrrole; pyrene; DNA/RNA binding; fluorescence; CD

Sažetak
A novel pyrene-guanidiniocarbonyl-pyrrole dye, characterised by a short, rigid linker between the two chromophores, interacts strongly with ds-DNA but only negligibly with ds-RNA. At neutral conditions the dye shows strong selectivity toward AT-DNA (in respect to GC-DNA). Binding is accompanied by a specific ICD band at 350 nm and fluorescence quenching for all DNA/RNA studied. At pH 5 the affinity of the dye is reversed, now favouring GC-DNA over AT-DNA. A strong emission increase for AT-DNA is observed but quenching for GC-DNA.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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