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Pregled bibliografske jedinice broj: 736566

Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition


Madunić, Josip; Antica, Mariastefania; Cvjetko, Petra; Požgaj, Lidija; Matulić, Maja
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition // Cytotechnology, 68 (2016), 783-794 doi:10.1007/s10616-014-9829-6 (međunarodna recenzija, članak, znanstveni)


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Naslov
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition

Autori
Madunić, Josip ; Antica, Mariastefania ; Cvjetko, Petra ; Požgaj, Lidija ; Matulić, Maja

Izvornik
Cytotechnology (0920-9069) 68 (2016); 783-794

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
urokinase plasminogen activator ; plasminogen activator inhibitor-1 ; poly(ADP-ribose)polymerase-1 ; DNA damage

Sažetak
The urokinase plasminogen activator (uPA) system is a complex regulator of extracellular proteolysis which is involved in various physiological and pathological processes. The major components of this system are the serine protease uPA, two inhibitors PAI-1 and PAI-2, and the receptor uPAR. It has been previously shown by several groups that the uPA system has an important role in cancer progression and therefore its possible prognostic and therapeutic value has been evaluated. The aim of this study is to tackle the role of poly(ADP-ribosyl)ation in the induction of uPA activity in a glioblastoma cell line, A1235. This cell line is sensitive to alkylation damage and is a model for drug treatment. The components of the uPA system and the level of DNA damage were analyzed after alkylation agent treatment in combination with poly(ADP- ribose)polymerase-1 (PARP-1) inhibition. Here we show that the increase in uPA activity results from the net balance change between uPA and its inhibitor on mRNA level. Further, PARP- 1 inhibition exerts its influence on uPA activity through DNA damage increase. Involvement of several signaling pathways, as well as cell specific regulation influencing the uPA system is discussed

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Mariastefania Antica, )
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Maja Matulić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Madunić, Josip; Antica, Mariastefania; Cvjetko, Petra; Požgaj, Lidija; Matulić, Maja
Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition // Cytotechnology, 68 (2016), 783-794 doi:10.1007/s10616-014-9829-6 (međunarodna recenzija, članak, znanstveni)
Madunić, J., Antica, M., Cvjetko, P., Požgaj, L. & Matulić, M. (2016) Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition. Cytotechnology, 68, 783-794 doi:10.1007/s10616-014-9829-6.
@article{article, year = {2016}, pages = {783-794}, DOI = {10.1007/s10616-014-9829-6}, keywords = {urokinase plasminogen activator, plasminogen activator inhibitor-1, poly(ADP-ribose)polymerase-1, DNA damage}, journal = {Cytotechnology}, doi = {10.1007/s10616-014-9829-6}, volume = {68}, issn = {0920-9069}, title = {Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition}, keyword = {urokinase plasminogen activator, plasminogen activator inhibitor-1, poly(ADP-ribose)polymerase-1, DNA damage} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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