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Pregled bibliografske jedinice broj: 736272

Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals


Weber, David A.; Ivanović, Marija; Franceschi, Dinko; Strand, Sven E.; Erlandsson, Kjell; Franceschi, Maja; Atkins, Harold L.; Ljunggren, Kaj; Button, Terry; Coderre, Jeffrey A.; Susskind, Herbert
Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals // Journal of Nuclear Medicine, 35 (1994), 2; 342-348 (međunarodna recenzija, članak, znanstveni)


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Naslov
Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals

Autori
Weber, David A. ; Ivanović, Marija ; Franceschi, Dinko ; Strand, Sven E. ; Erlandsson, Kjell ; Franceschi, Maja ; Atkins, Harold L. ; Ljunggren, Kaj ; Button, Terry ; Coderre, Jeffrey A. ; Susskind, Herbert

Izvornik
Journal of Nuclear Medicine (0161-5505) 35 (1994), 2; 342-348

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pinhole SPECT ; technetium-99m- MIBI ; technetium-99m-DTPA ; technetium-99m-HMPAO ; thallium-201-chloride ; tumor imaging

Sažetak
The performance of pinhole SPECT and the application of this technology to investigate the localization properties of radiopharmaceuticals in vivo in small laboratory animals are presented. Methods: System sensitivity and spatial resolution measurements of a rotating scintillation camera system are made for a low-energy pinhole collimator equipped with 1.0-, 2.0- and 3.3-mm aperture pinhole inserts. The spatial detail offered by pinhole SPECT for in vivo imaging was investigated studies of the brain and heart in Fisher 344 rats by administering 201TICI, 99mTc-HMPAO, 99mTc-DTPA and 99mTc- MIBI. Image acquisition is performed using a rotating scintillation camera equipped with a pinhole collimator projection data are acquired in conventional step-and-shoot mode as the camera is rotated 360° around the subject. Pinhole SPECT images are reconstructed using a modified cone-beam algorithm developed from a two-dimensional fanbeam filtered backprojection algorithm. Results: The reconstructed transaxial resolution of 2.8 mm FWHM and system sensitivity of 0.086 c/s/kBq with the 2.0-mm pinhole collimator aperture provide excellent spatial detail and adequate sensitivity for imaging the regional uptake of the radiopharmaceuticals in tumor, organs and other tissues in small laboratory animals. Conclusion: The resolution properties of pinhole SPECT are superior to those which have been achieved thus far with conventional SPECT or PET imaging technologies. Pinhole SPECT provides an important approach for investigating localization properties of radiopharmaceuticals in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Marija Ivanović (autor)

Avatar Url Maja Franceschi (autor)

Avatar Url Dinko Franceschi (autor)


Citiraj ovu publikaciju:

Weber, David A.; Ivanović, Marija; Franceschi, Dinko; Strand, Sven E.; Erlandsson, Kjell; Franceschi, Maja; Atkins, Harold L.; Ljunggren, Kaj; Button, Terry; Coderre, Jeffrey A.; Susskind, Herbert
Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals // Journal of Nuclear Medicine, 35 (1994), 2; 342-348 (međunarodna recenzija, članak, znanstveni)
Weber, D., Ivanović, M., Franceschi, D., Strand, S., Erlandsson, K., Franceschi, M., Atkins, H., Ljunggren, K., Button, T., Coderre, J. & Susskind, H. (1994) Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals. Journal of Nuclear Medicine, 35 (2), 342-348.
@article{article, author = {Weber, David A. and Ivanovi\'{c}, Marija and Franceschi, Dinko and Strand, Sven E. and Erlandsson, Kjell and Franceschi, Maja and Atkins, Harold L. and Ljunggren, Kaj and Button, Terry and Coderre, Jeffrey A. and Susskind, Herbert}, year = {1994}, pages = {342-348}, keywords = {pinhole SPECT, technetium-99m- MIBI, technetium-99m-DTPA, technetium-99m-HMPAO, thallium-201-chloride, tumor imaging}, journal = {Journal of Nuclear Medicine}, volume = {35}, number = {2}, issn = {0161-5505}, title = {Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals}, keyword = {pinhole SPECT, technetium-99m- MIBI, technetium-99m-DTPA, technetium-99m-HMPAO, thallium-201-chloride, tumor imaging} }
@article{article, author = {Weber, David A. and Ivanovi\'{c}, Marija and Franceschi, Dinko and Strand, Sven E. and Erlandsson, Kjell and Franceschi, Maja and Atkins, Harold L. and Ljunggren, Kaj and Button, Terry and Coderre, Jeffrey A. and Susskind, Herbert}, year = {1994}, pages = {342-348}, keywords = {pinhole SPECT, technetium-99m- MIBI, technetium-99m-DTPA, technetium-99m-HMPAO, thallium-201-chloride, tumor imaging}, journal = {Journal of Nuclear Medicine}, volume = {35}, number = {2}, issn = {0161-5505}, title = {Pinhole SPECT: An Approach to In Vivo High Resolution SPECT Imaging in Small Laboratory Animals}, keyword = {pinhole SPECT, technetium-99m- MIBI, technetium-99m-DTPA, technetium-99m-HMPAO, thallium-201-chloride, tumor imaging} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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