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Pregled bibliografske jedinice broj: 735493

Management of Cushing's disease : single center experience


Melada, Ante; Solak, Mirsala; Marjanović-Kavanagh, Marcel; Peterković, Vjerislav; Kraljević, Ivana; Dušek, Tina; Ozretić, David; Kaštelan, Darko
Management of Cushing's disease : single center experience // Endocrine (Basingstoke), 51 (2016), 3; 517-523 doi:10.1007/s12020-015-0695-6 (recenziran, članak, znanstveni)


Naslov
Management of Cushing's disease : single center experience

Autori
Melada, Ante ; Solak, Mirsala ; Marjanović-Kavanagh, Marcel ; Peterković, Vjerislav ; Kraljević, Ivana ; Dušek, Tina ; Ozretić, David ; Kaštelan, Darko

Izvornik
Endocrine (Basingstoke) (1355-008X) 51 (2016), 3; 517-523

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cushing's disease ; Pituitary adenoma ; Transsphenoidal surgery ; Remission ; Comorbidity

Sažetak
The purpose of this study was to review therapeutic outcomes and comorbidities of patients with Cushing's disease (CD) in a single center. We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014 (27 females and 6 males, median age 38 years, range 18-71 years). The diagnosis of Cushing's syndrome was established on the basis of the patient's history, characteristic clinical features, and laboratory data including an elevated 24-h urinary free cortisol level, lack of serum cortisol suppression after dexamethasone suppression tests and an elevated midnight cortisol level. In 28/33 patients, the tumor was visualized on MR of the sellar region, while in 5 it was diagnosed using an inferior petrosal sinus sampling. Out of the 33 patients, 10 had macroadenoma and the remaining 23 had microadenoma. Twenty-one patients (63.6 %) had hypertension, 17 (51.5 %) dyslipidemia, and 7 (21.2 %) had type 2 diabetes or impaired glucose tolerance. The median follow-up period was 28 months. Remission after transsphenoidal surgery was achieved in 78.8 % of patients, while 7 patients failed to achieve disease remission. Those patients were treated with second-line treatment modalities (second operation, radiotherapy, bilateral adrenalectomy, and/or ketoconazole). One patient rejected all the treatment modalities after surgery. Cumulative remission after all the treatment modalities was achieved in 87.9 % patients. Patients with Cushing's disease should be managed in centers with much experience due to high patient load. In our Center, the remission of the disease has been achieved in 78.8 % of the patients following transsphenoidal surgery. Multimodal treatment which included radiotherapy and medical treatment led to biochemical remission of the disease in 87.9 % of patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Melada, Ante; Solak, Mirsala; Marjanović-Kavanagh, Marcel; Peterković, Vjerislav; Kraljević, Ivana; Dušek, Tina; Ozretić, David; Kaštelan, Darko
Management of Cushing's disease : single center experience // Endocrine (Basingstoke), 51 (2016), 3; 517-523 doi:10.1007/s12020-015-0695-6 (recenziran, članak, znanstveni)
Melada, A., Solak, M., Marjanović-Kavanagh, M., Peterković, V., Kraljević, I., Dušek, T., Ozretić, D. & Kaštelan, D. (2016) Management of Cushing's disease : single center experience. Endocrine (Basingstoke), 51 (3), 517-523 doi:10.1007/s12020-015-0695-6.
@article{article, year = {2016}, pages = {517-523}, DOI = {10.1007/s12020-015-0695-6}, keywords = {Cushing's disease, Pituitary adenoma, Transsphenoidal surgery, Remission, Comorbidity}, journal = {Endocrine (Basingstoke)}, doi = {10.1007/s12020-015-0695-6}, volume = {51}, number = {3}, issn = {1355-008X}, title = {Management of Cushing's disease : single center experience}, keyword = {Cushing's disease, Pituitary adenoma, Transsphenoidal surgery, Remission, Comorbidity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


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