Napredna pretraga

Pregled bibliografske jedinice broj: 73545

Postnatal development of human CA1 pyramidal neurons


Šimić, Goran; Bjeloš, Mirjana; Rašin, Mladen R.; Laszlo, Seress; Kostović, Ivica
Postnatal development of human CA1 pyramidal neurons // Abstracts of Annual Meeting of Society for Neuroscience ; u: Society for Neuroscience Abstracts
San Diego: Society for Neuroscience, 2001. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Postnatal development of human CA1 pyramidal neurons

Autori
Šimić, Goran ; Bjeloš, Mirjana ; Rašin, Mladen R. ; Laszlo, Seress ; Kostović, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of Annual Meeting of Society for Neuroscience ; u: Society for Neuroscience Abstracts / - San Diego : Society for Neuroscience, 2001

Skup
Annual Meeting of Society for Neuroscience

Mjesto i datum
San Diego, SAD, 10.-15.11.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Development; declarative memory; human hippocampus; pyramidal neurons

Sažetak
So far the data on the postnatal hippocampal development has been resctricted to available experimental animal models. The aim of the present study therefore was to examine the postnatal development of the human hippocampal pyramidal neurons. By using the rapid Golgi technique we analyzed tissue blocks with short postmortem intervals from the left hippocampi of five neurologically normal children (1, 3, 8 and 11 months, and 3 years of age) and two adults (19 and 50 years of age). The quantification of 10 dendritic parameters and 7 parameters related to dendritic spines of CA1 pyramidal neurons was carried out on a Neurolucida microscope/computer interface system (Microbrightfield, Inc.). The results revealed that most of the parameters progressively rise from birth to 3 years of age. At this age the total dendritic spine number reached about 97% of adult values for basal and about 150% for apical dendrites, while the total dendritic length was about 47% of adult values for basal and 99% for apical dendrites. Comparing the mean spine densities (number of spines per micrometer) for 3 year stage vs adult (0.76 vs 0.37 for apical and 0.73 vs 0.49 for basal) it can be seen that spine density declines only after 3 years of age for both apical (because of spine loss) and basal dendrites (mostly due to dendritic lengthening). We conclude that the development of human hippocampus is very protracted. This prolonged maturation of CA1 pyramidal neurons in man, which parallels with previous description for mossy cells in the human dentate gyrus (Seress and Mrzljak, 1992), indicates slow development of structural basis of human declarative memory.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108118

Ustanove
Medicinski fakultet, Zagreb

Autor s matičnim brojem:
Goran Šimić, (198614)