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Hair silver median derivates for the assessment of the environmental silver exposure, overexposure, and toxicity (CROSBI ID 212536)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Momčilović, Berislav ; Prejac, Juraj ; Višnjević, Vjeran ; Mimica, Ninoslav ; Skalny, Anatoly V. ; Morović, Sandra ; Čelebić, Asja Hair silver median derivates for the assessment of the environmental silver exposure, overexposure, and toxicity // Mikroèlementy v medicine = Trace elements in medicine, 13 (2012), 3; 27-36

Podaci o odgovornosti

Momčilović, Berislav ; Prejac, Juraj ; Višnjević, Vjeran ; Mimica, Ninoslav ; Skalny, Anatoly V. ; Morović, Sandra ; Čelebić, Asja

engleski

Hair silver median derivates for the assessment of the environmental silver exposure, overexposure, and toxicity

Silver was analyzed in the hair of 213 occupationally non- exposed subjects (87 men, 126 women) with the inductively coupled plasma mass spectrometry (ICP MS). Median hair Ag con- centration was 0.070 jlig/g for both sexes combined ; but women's hair have more Ag than that of men (p < 0.05, Chi square test). The hair silver below 0.010 (ig/g and 0.015 [ig/g for men and women, re-spectively, appeared to be toxicologically irrelevant, and to only reflect random silver distribution between the other biochemical compartments of the human body. Above that concentration level hair silver con- centration diverges upward, first for men and then for women and rose rapidly in a parallel type biological assay pattern, indicating the physiological saturation mechanism. These t\vo distinct parallel saturation curves for men and women would converge back to the common sigmoid overexposure plateau at 0.210 jug/g and 0.358 jug/g for men and women, re-spectively. Combined with the medical history, our data indicate the hair silver of 2.00 jug/g to reflect clinical sub toxicity, and its concentrations above 4.00 fig/g an overt neurotoxicity.

hair silver ; exposure ; overexposure ; toxicity ; median derivates ; logistic fit

Sažetak i na ruskom jeziku.

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Podaci o izdanju

13 (3)

2012.

27-36

objavljeno

1607-9957

2413-6174

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti