engleski

Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder

The aim of this study was to measure the parameters of oxidative stress in the blood of patients with post-traumatic stress disorder. The study included 80 male war veterans who participated actively in the Homeland war in Croatia. Volunteers were divided into two groups: 50 veterans diagnosed with post-traumatic stress disorder and 30 vvithout diagnosis. The self-assessment Hospital Anxiety and Depression Scale and the Beck Depression lnventory were used to detect the severity of depression and anxiety in the post- traumatic stress disorder patients. Catalytic concentrations of superoxide dismutase and glutathione peroxidase in erythrocytes and the concentration of malondialdehyde in serum were measured spectrophotometrically. Although the catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione per-oxidase were within the reference range for both groups, the values obtained for the post-traumatic stress disorder group were significantly lower (P< 0.001). For serum malondialdehyde concentrations, no statistically significant differ- ences between the groups were found. Lower catalytic concentrations of erythrocyte superoxide dismutase and erythrocyte glutathione perox- idase in patients with post-traumatic stress disorder may indicate a weaker response to oxidative stress due to impaired enzyme activity and/or decreased synthesis. Conversely, no significant changes in serum malondialdehyde concentrations suggest a compensated balance and adaptive response to (oxidative) stress.

enzymes; nutrition; enzymatic methods

nije evidentirano