Napredna pretraga

Pregled bibliografske jedinice broj: 734307

One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension


Samardžija, Miroslav; Žuljević, Ervin; Jakopović, Marko; Sever, Branko; Knežević, Aleksandar; Đumija, Željko; Vidjak, Vinko; Šamija, Mirko
One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension // Collegium antropologicum, 33 (2009), 3; 799-803 (međunarodna recenzija, članak, znanstveni)


Naslov
One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension

Autori
Samardžija, Miroslav ; Žuljević, Ervin ; Jakopović, Marko ; Sever, Branko ; Knežević, Aleksandar ; Đumija, Željko ; Vidjak, Vinko ; Šamija, Mirko

Izvornik
Collegium antropologicum (0350-6134) 33 (2009), 3; 799-803

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pulmonary hypertension; idiopathic; chronic thrombo-embolic; sildenafil; 6-minute walk test

Sažetak
Severe pulmonary hypertension is a progressive disease which leads to limitations of functional status and poor survival. We evaluated efficacy and safety of a short (3 months) and a long term (12 months) sildenafil treatment in patients with severe pulmonary hypertension. We treated 12 patients with pulmonary hypertension with oral sildenafil. Patients were followed at three time points, at baseline, and after 3 and 12 months of treatment. Primary end point was improvement in functional exercise capacity assesed by 6- minute walk test, and secondary end points were changes in right ventricle hemodynamics. We found significant improvement in 6-minute walk test distance from 357±193 m at baseline to 431±179 m after three months and further improvement to 501±159 m after 12 months (p<0.01) ; decrease in right ventricule pressure from 107±42 mmHg at baseline to 87±32 mmHg after 12 months (p<0.01) ; and, decrease in right ventricule diameter from 3.2±1.1cm to 2.76±0.86 cm after twelve months (p<0.01). Drug-related adverse events were mild and transient in our group of patients. Long term (12 months) sildenafil treatment is effective and safe in our patients with idiopathic and chronic thrombo-embolic pulmonary hypertension.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinička bolnica "Merkur",
Klinika za tumore,
Opća bolnica Zadar,
Klinika za plućne bolesti "Jordanovac"

Citiraj ovu publikaciju

Samardžija, Miroslav; Žuljević, Ervin; Jakopović, Marko; Sever, Branko; Knežević, Aleksandar; Đumija, Željko; Vidjak, Vinko; Šamija, Mirko
One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension // Collegium antropologicum, 33 (2009), 3; 799-803 (međunarodna recenzija, članak, znanstveni)
Samardžija, M., Žuljević, E., Jakopović, M., Sever, B., Knežević, A., Đumija, Ž., Vidjak, V. & Šamija, M. (2009) One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension. Collegium antropologicum, 33 (3), 799-803.
@article{article, year = {2009}, pages = {799-803}, keywords = {pulmonary hypertension, idiopathic, chronic thrombo-embolic, sildenafil, 6-minute walk test}, journal = {Collegium antropologicum}, volume = {33}, number = {3}, issn = {0350-6134}, title = {One Year Efficacy of Oral Sildenafil Treatment in Severe Pulmonary Hypertension}, keyword = {pulmonary hypertension, idiopathic, chronic thrombo-embolic, sildenafil, 6-minute walk test} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE