Napredna pretraga

Pregled bibliografske jedinice broj: 734280

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies


Murabito, Joanne M.; White, Charles C.; Kavousi, Maryam; Sun, Yan V.; Feitosa, Mary F.; Nambi, Vijay; Lamina, Claudia; Schillert, Arne; Coassin, Stefan; Bis, Joshua C. et al.
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies // Circulation : cardiovascular genetics, 5 (2012), 1; 100-112 doi:10.1161/CIRCGENETICS.111.961292 (međunarodna recenzija, članak, znanstveni)


Naslov
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

Autori
Murabito, Joanne M. ; White, Charles C. ; Kavousi, Maryam ; Sun, Yan V. ; Feitosa, Mary F. ; Nambi, Vijay ; Lamina, Claudia ; Schillert, Arne ; Coassin, Stefan ; Bis, Joshua C. ; Broer, Linda ; Crawford, Dana C. ; Franceschini, Nora ; Frikke-Schmidt, Ruth ; Haun, Margot ; Holewijn, Suzanne ; Huffman, Jennifer E. ; Hwang, Shih-Jen ; Kiechl, Stefan ; Kollerits, Barbara ; Montasser, May E. ; Nolte, Ilja M. ; Rudock, Megan E. ; Senft, Andrea ; Teumer, Alexander ; van der Harst, Pim ; Vitart, Veronique ; Waite, Lindsay L. ; Wood, Andrew R. ; Wassel, Christina L. ; Absher, Devin M. ; Allison, Matthew A. ; Amin, Najaf ; Arnold, Alice ; Asselbergs, Folkert W. ; Aulchenko, Yurii ; Bandinelli, Stefania ; Barbalić, Maja ; Boban, Mladen ; Brown-Gentry, Kristin ; Couper, David J. ; Criqui, Michael H. ; Dehghan, Abbas ; den Heijer, Martin ; Dieplinger, Benjamin ; Ding, Jingzhong ; Doerr, Marcus ; Espinola-Klein, Christine ; Felix, Stephan B. ; Ferrucci, Luigi ; Folsom, Aaron R. ; Fraedrich, Gustav ; Gibson, Quince ; Goodloe, Robert ; Gunjača, Grgo ; Haltmayer, Meinhard ; Heiss, Gerardo ; Hofman, Albert ; Kieback, Arne ; Kiemeney, Lambertus A. ; Kolčić, Ivana ; Kullo, Iftikhar J. ; Kritchevsky, Stephen B. ; Lackner, Karl J. ; Li, Xiaohui ; Lieb, Wolfgang ; Lohman, Kurt ; Meisinger, Christa ; Melzer, David ; Mohler, Emile R. ; Mudnić, Ivana ; Mueller, Thomas ; Navis, Gerjan ; Oberhollenzer, Friedrich ; Olin, Jeffrey W. ; O'Connell, Jeff ; O'Donnell, Christopher J. ; Palmas, Walter ; Penninx, Brenda W. ; Petersmann, Astrid ; Polašek, Ozren ; Psaty, Bruce M. ; Rantner, Barbara ; Rice, Ken ; Rivadeneira, Fernando ; Rotter, Jerome I. ; Seldenrijk, Adrie ; Stadler, Marietta ; Summerer, Monika ; Tanaka, Toshiko ; Tybjaerg-Hansen, Anne ; Uitterlinden, Andre G. ; van Gilst, Wiek H. ; Vermeulen, Sita H. ; Wild, Sarah H. ; Wild, Philipp S. ; Willeit, Johann ; Zeller, Tanja ; Zemunik, Tatijana ; Zgaga, Lina ; Assimes, Themistocles L. ; Blankenberg, Stefan ; Boerwinkle, Eric ; Campbell, Harry ; Cooke, John P. ; de Graaf, Jacqueline ; Herrington, David ; Kardia, Sharon L. R. ; Mitchell, Braxton D. ; Murray, Anna ; Muenzel, Thomas ; Newman, Anne B. ; Oostra, Ben A. ; Rudan, Igor ; Shuldiner, Alan R. ; Snieder, Harold ; van Duijn, Cornelia M. ; Voelker, Uwe ; Wright, Alan F. ; Wichmann, H. Erich ; Wilson, James F. ; Witteman, Jacqueline C. M. ; Liu, Yongmei ; Hayward, Caroline ; Borecki, Ingrid B. ; Ziegler, Andreas ; North, Kari E. ; Cupples, L. Adrienne ; Kronenberg, Florian

Izvornik
Circulation : cardiovascular genetics (1942-3268) 5 (2012), 1; 100-112

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cohort study; genetic association; genome-wide association study; meta-analysis; peripheral vascular disease

Sažetak
Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Continuous ABI and PAD (ABI ≤0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ≈2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed effects inverse variance weighted meta-analyses. There were a total of 41 692 participants of European ancestry (≈60% women, mean ABI 1.02 to 1.19), including 3409 participants with PAD and with genome-wide association study data available. In the discovery meta-analysis, rs10757269 on chromosome 9 near CDKN2B had the strongest association with ABI (β=-0.006, P=2.46×10(-8)). We sought replication of the 6 strongest SNP associations in 5 population-based studies and 3 clinical samples (n=16 717). The association for rs10757269 strengthened in the combined discovery and replication analysis (P=2.65×10(-9)). No other SNP associations for ABI or PAD achieved genome-wide significance. However, 2 previously reported candidate genes for PAD and 1 SNP associated with coronary artery disease were associated with ABI: DAB21P (rs13290547, P=3.6×10(-5)), CYBA (rs3794624, P=6.3×10(-5)), and rs1122608 (LDLR, P=0.0026). Genome-wide association studies in more than 40 000 individuals identified 1 genome wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for coronary artery disease are associated with ABI.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
216-2160547-0537 - Kardiovaskularni učinci vina i njegovih sastojaka (Mladen Boban, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati