Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 734017

Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis


Šain, Milenka; Kovačić, Vedran; Radić, Josipa, Ljutić, Dragan; Jeličić Ivo
Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis // Drugs & aging, 29 (2012), 1; 1-7 doi:10.2165/11592870-000000000-00000 (recenziran, članak, stručni)


CROSBI ID: 734017 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis

Autori
Šain, Milenka ; Kovačić, Vedran ; Radić, Josipa, Ljutić, Dragan ; Jeličić Ivo

Izvornik
Drugs & aging (1170-229X) 29 (2012), 1; 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
low molecular weight heparin; cognitive function

Sažetak
Vascular cognitive impairment or mixed vascular cognitive impairment and Alzheimer's disease (AD) appear to be much more common in elderly patients than AD alone. Furthermore, vascular dementia (VaD) and AD are more prevalent in elderly patients receiving haemodialysis (HD), leading to a loss of independence and a poor quality of life. Hypotensive episodes in patients receiving HD contribute to vascular changes in the brain, with consequent progression of VaD and AD. The use of the lowest individually optimized bolus dose of low molecular weight heparin (LMWH) during HD, with fewer hypotensive episodes during and between HD procedures, may exert a sparing effect on changes in microvascular circulation and decrease the incidence of VaD and AD. We believe that long-term use of LMWH, with its direct effect on amyloid β protein (Aβ) in the blood and on Aβ accumulation in the brain and indirect effects on prevention of complement activation, may delay the progression of cognitive impairment in patients receiving HD. There is a need for a robustly designed, prospective trial to evaluate the effects of long-term treatment with LMWH on mild cognitive impairment, VaD and AD in elderly patients receiving maintenance HD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split

Profili:

Avatar Url Ivo Jeličić (autor)

Avatar Url Milenka Šain (autor)

Avatar Url Vedran Kovačić (autor)

Citiraj ovu publikaciju

Šain, Milenka; Kovačić, Vedran; Radić, Josipa, Ljutić, Dragan; Jeličić Ivo
Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis // Drugs & aging, 29 (2012), 1; 1-7 doi:10.2165/11592870-000000000-00000 (recenziran, članak, stručni)
Šain, M., Kovačić, V., Radić, Josipa, Ljutić, Dragan & Jeličić Ivo (2012) Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis. Drugs & aging, 29 (1), 1-7 doi:10.2165/11592870-000000000-00000.
@article{article, year = {2012}, pages = {1-7}, DOI = {10.2165/11592870-000000000-00000}, keywords = {low molecular weight heparin, cognitive function}, journal = {Drugs and aging}, doi = {10.2165/11592870-000000000-00000}, volume = {29}, number = {1}, issn = {1170-229X}, title = {Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis}, keyword = {low molecular weight heparin, cognitive function} }
@article{article, year = {2012}, pages = {1-7}, DOI = {10.2165/11592870-000000000-00000}, keywords = {low molecular weight heparin, cognitive function}, journal = {Drugs and aging}, doi = {10.2165/11592870-000000000-00000}, volume = {29}, number = {1}, issn = {1170-229X}, title = {Potential beneficial effects of low molecular weight heparin on cognitive impairment in elderly patients on haemodialysis}, keyword = {low molecular weight heparin, cognitive function} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font